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Applications of mass spectrometry imaging in virus research.
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- Author(s): Bertzbach LD;Bertzbach LD; Kaufer BB; Kaufer BB; Karger A; Karger A
- Source:
Advances in virus research [Adv Virus Res] 2021; Vol. 109, pp. 31-62. Date of Electronic Publication: 2020 Nov 09.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Academic Press Country of Publication: United States NLM ID: 0370441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8399 (Electronic) Linking ISSN: 00653527 NLM ISO Abbreviation: Adv Virus Res Subsets: MEDLINE
- Publication Information: Original Publication: New York, NY : Academic Press
- Subject Terms: Research*; Mass Spectrometry/*methods ; Molecular Imaging/*methods ; Viruses/*chemistry; Animals ; Books ; Humans ; Mass Spectrometry/instrumentation ; Metabolomics ; Molecular Imaging/instrumentation ; Oncogenic Viruses/pathogenicity ; Plant Viruses/pathogenicity ; Plants/virology ; Proteome/metabolism ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Viruses/genetics
- Abstract: Mass spectrometry imaging (MSI) is a label-free molecular imaging technique allowing an untargeted detection of a broad range of biomolecules and xenobiotics. MSI enables imaging of the spatial distribution of proteins, peptides, lipids and metabolites from a wide range of samples. To date, this technique is commonly applied to tissue sections in cancer diagnostics and biomarker development, but also molecular histology in general. Advances in the methodology and bioinformatics improved the resolution of MS images below the single cell level and increased the flexibility of the workflow. However, MSI-based research in virology is just starting to gain momentum and its full potential has not been exploited yet. In this review, we discuss the main applications of MSI in virology. We review important aspects of matrix-assisted laser desorption/ionization (MALDI) MSI, the most widely used MSI technique in virology. In addition, we summarize relevant literature on MSI studies that aim to unravel virus-host interactions and virus pathogenesis, to elucidate antiviral drug kinetics and to improve current viral disease diagnostics. Collectively, these studies strongly improve our general understanding of virus-induced changes in the proteome, metabolome and metabolite distribution in host tissues of humans, animals and plants upon infection. Furthermore, latest MSI research provided important insights into the drug distribution and distribution kinetics, especially in antiretroviral research. Finally, MSI-based investigations of oncogenic viruses greatly increased our knowledge on tumor mass signatures and facilitated the identification of cancer biomarkers.
(Copyright © 2021 Elsevier Inc. All rights reserved.) - Contributed Indexing: Keywords: Flaviviruses; Hepatitis viruses; Herpesviruses; Mass spectrometry imaging; Molecular imaging; Papillomaviruses; Plant viruses; Proteomics; Retroviruses; Tumor viruses
- Accession Number: 0 (Proteome)
- Publication Date: Date Created: 20210503 Date Completed: 20211008 Latest Revision: 20211008
- Publication Date: 20221213
- Accession Number: 10.1016/bs.aivir.2020.10.002
- Accession Number: 33934829
- Source:
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