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An observational study to identify the prevalence of thrombocytopenia and anti-PF4/polyanion antibodies in Norwegian health care workers after COVID-19 vaccination.
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- Author(s): Sørvoll IH;Sørvoll IH; Horvei KD; Horvei KD; Ernstsen SL; Ernstsen SL; Laegreid IJ; Laegreid IJ; Lund S; Lund S; Grønli RH; Grønli RH; Olsen MK; Olsen MK; Jacobsen HK; Jacobsen HK; Eriksson A; Eriksson A; Halstensen AM; Halstensen AM; Tjønnfjord E; Tjønnfjord E; Ghanima W; Ghanima W; Ghanima W; Ahlen MT; Ahlen MT
- Source:
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2021 Jul; Vol. 19 (7), pp. 1813-1818. Date of Electronic Publication: 2021 May 18.- Publication Type:
Journal Article; Observational Study- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
- Publication Information: Publication: 2023- : [New York] : Elsevier
Original Publication: Oxford : Blackwell Pub. - Subject Terms:
- Abstract: Background: The COVID-19 vaccine from AstraZeneca (AZD1222) is one of several vaccines introduced to provide immunity against SARS-CoV-2. Recently, more than 50 cases have been reported presenting a combination of thrombosis, thrombocytopenia, and remarkably high levels of anti-platelet factor 4 (PF4)/polyanion antibodies post-AZD1222 vaccination. Now linked to the vaccine, the condition is referred to as vaccine-induced immune thrombotic thrombocytopenia. The European Medicines Agency still recommends vaccination with AZD1222, but several European countries have temporally paused and/or restricted its use because of the perceived risk of this severe side effect. Because there is no description of PF4/polyanion antibody testing in the clinical trials, knowledge about the prevalence of such antibodies in a vaccinated cohort is needed.
Objectives: To investigate prevalence of thrombocytopenia and anti-PF4/polyanion antibodies in a population recently vaccinated with AZD1222.
Patients/methods: Four hundred and ninety-two health care workers recently vaccinated with the first dose of AZD1222 were recruited from two hospitals in Norway. Study individuals were screened for thrombocytopenia and the presence of anti-PF4/polyanion antibodies with a PF4/PVS immunoassay. Side effects after vaccination were registered.
Results: The majority of study participants had normal platelet counts and negative immunoassay. Anti-PF4/polyanion antibodies without platelet activating properties were only detected in six individuals (optical density ≥0.4, range 0.58-1.16), all with normal platelet counts. No subjects had severe thrombocytopenia.
Conclusions: We found low prevalence of both thrombocytopenia and antibodies to PF4/polyanion-complexes among Norwegian health care workers after vaccination with AZD1222.
(© 2021 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.) - References: Lancet. 2021 Jan 9;397(10269):99-111. (PMID: 33306989)
Lancet. 2020 Aug 15;396(10249):467-478. (PMID: 32702298)
N Engl J Med. 2001 Apr 26;344(17):1286-92. (PMID: 11320387)
N Engl J Med. 2021 Jun 10;384(23):2202-2211. (PMID: 33861525)
J Thromb Haemost. 2017 Nov;15(11):2099-2114. (PMID: 28846826)
Lancet. 2021 Dec 19;396(10267):1979-1993. (PMID: 33220855)
N Engl J Med. 2021 Jun 3;384(22):2092-2101. (PMID: 33835769)
N Engl J Med. 2021 Jun 3;384(22):2124-2130. (PMID: 33835768)
Am J Clin Pathol. 2010 Nov;134(5):774-80. (PMID: 20959660)
Platelets. 2013;24(6):441-7. (PMID: 22994796)
Lancet. 2021 Mar 6;397(10277):881-891. (PMID: 33617777) - Grant Information: 2020/1100 Helse Nord RHF
- Contributed Indexing: Keywords: COVID-19 vaccines; COVID-19 vaccines/adverse effects; drug related side effects and adverse reactions; platelet factor 4; thrombocytopenia
- Accession Number: 0 (COVID-19 Vaccines)
0 (Polyelectrolytes)
0 (polyanions)
37270-94-3 (Platelet Factor 4)
9005-49-6 (Heparin)
B5S3K2V0G8 (ChAdOx1 nCoV-19) - Publication Date: Date Created: 20210428 Date Completed: 20210630 Latest Revision: 20230829
- Publication Date: 20231215
- Accession Number: PMC8237070
- Accession Number: 10.1111/jth.15352
- Accession Number: 33909350
- Source:
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