Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      Biomarkers/*metabolism ; Blood Glucose/*metabolism ; Diabetes Mellitus, Type 2/*physiopathology ; Hyperglycemia/*epidemiology ; Hypoglycemia/*epidemiology; Aged ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Glycated Hemoglobin/analysis ; Humans ; Hyperglycemia/metabolism ; Hyperglycemia/pathology ; Hypoglycemia/metabolism ; Hypoglycemia/pathology ; Incidence ; Insulin Secretion ; Japan/epidemiology ; Male ; Middle Aged ; Prospective Studies
    • Abstract:
      The contribution of endogenous insulin secretion to glycemic variability (GV) may differ between patients with impaired insulin secretion and those with preserved secretion. Our objective was to determine the linearity of the relationship between fasting C-peptide (CPR) as a marker of endogenous insulin secretion and GV in type 2 diabetes (T2DM), regardless of the type of antidiabetic treatment. We conducted a prospective observational study using continuous glucose monitoring obtained from 284 Japanese outpatients with T2DM with various HbA1c values and antidiabetic treatment. We constructed a prediction curve of base-line CPR versus coefficient of variation (CV) and identified the clinical factors associated with CV using multiple regression analysis. Fasting CPR showed a significant negative log-linear relationship with CV (P < 0.0001), and the latter being strikingly high in the low-CPR group. The multiple regression analysis showed that low CPR was an independent predictor of high CV (P < 0.0001). The significant correlations were sustained in both patients with/without insulin treatment. The contribution of endogenous insulin secretion to GV depends on the extent of insulin secretion impairment. Fasting CPR may represent a useful indicator of GV instability in T2DM.
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    • Accession Number:
      0 (Biomarkers)
      0 (Blood Glucose)
      0 (Glycated Hemoglobin A)
      0 (hemoglobin A1c protein, human)
    • Publication Date:
      Date Created: 20210428 Date Completed: 20211014 Latest Revision: 20221207
    • Publication Date:
      20221213
    • Accession Number:
      PMC8079412
    • Accession Number:
      10.1038/s41598-021-88749-9
    • Accession Number:
      33907279