Particulate Matter-Induced Cardiovascular Dysfunction: A Mechanistic Insight.

Publisher: Humana Press Country of Publication: United States NLM ID: 101135818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0259 (Electronic) Linking ISSN: 15307905 NLM ISO Abbreviation: Cardiovasc Toxicol Subsets: MEDLINE

Original Publication: Totowa, NJ : Humana Press, c2001-

Air Pollutants/*adverse effects ; Air Pollution/*adverse effects ; Cardiovascular Diseases/*chemically induced ; Cardiovascular System/*drug effects ; Environmental Exposure/*adverse effects ; Particulate Matter/*adverse effects; Animals ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/physiopathology ; Cardiovascular System/metabolism ; Cardiovascular System/physiopathology ; Epigenesis, Genetic/drug effects ; Humans ; Inflammation Mediators/metabolism ; Oxidative Stress/drug effects ; Particle Size ; Prognosis ; Risk Assessment ; Risk Factors ; Time Factors

Air pollution and particulate matter (PM) are significant factors for adverse health effects most prominently cardiovascular disease (CVD). PM is produced from various sources, which include both natural and anthropogenic. It is composed of biological components, organic compounds, minerals, and metals, which are responsible for inducing inflammation and adverse health effects. However, the adverse effects are related to PM size distribution. Finer particles are a significant cause of cardiovascular events. This review discusses the direct and indirect mechanisms of PM-induced CVD like myocardial infarction, the elevation of blood pressure, cardiac arrhythmias, atherosclerosis, and thrombosis. The two potential mechanisms are oxidative stress and systemic inflammation. Prenatal exposure has also been linked with cardiovascular outcomes later in life. Moreover, we also mentioned the epidemiological studies that strongly associate PM with CVD.

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Keywords: Air pollution; Cardiac arrhythmia; Cardiac failure; Cardiovascular diseases; PM 2.5

0 (Air Pollutants)
0 (Inflammation Mediators)
0 (Particulate Matter)

Date Created: 20210422 Date Completed: 20220207 Latest Revision: 20220207

20231215

10.1007/s12012-021-09652-3

33886046