Long-term prognosis analysis of PARACHUTE device implantation in patients with ischemic heart failure: a single-center experience of Chinese patients.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101265113 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-8090 (Electronic) Linking ISSN: 17498090 NLM ISO Abbreviation: J Cardiothorac Surg Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BioMed Central, 2006-
    • Subject Terms:
      Heart-Assist Devices*; Heart Failure/*surgery ; Myocardial Infarction/*surgery ; Prosthesis Implantation/*instrumentation; Adult ; Aged ; China ; Female ; Follow-Up Studies ; Heart Failure/etiology ; Heart Failure/pathology ; Heart Failure/physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Prognosis ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left ; Ventricular Remodeling
    • Abstract:
      Background: Heart failure (HF) is one of the leading causes of mortality and morbidity. The PARACHUTE device is designed to partition for left ventricular (LV) apical aneurysm post extensive anterior myocardial infarction (MI). However, the long-term prognosis of the PARACHUTE device post-implantation is unclear.
      Methods: From November 2015 to April 2017, six subjects with New York Heart Association Classes II, III and IV ischemic HF, LV ejection fraction between (LVEF) 15 and 40%; and LV anterior apical aneurysm were enrolled in our center. The cumulative event rates for MI, hospitalization, and mortality were documented. Further assessment of LVEF, LV end-diastolic diameter (LVEDD), and estimated pulmonary artery pressure were determined by echocardiography core laboratory. For quantitative data comparison, paired t-test was employed.
      Results: Device implantation was successful in all six enrolled subjects, and acute device association adverse events were not observed. At 4.6 ± 1.7 years follow-up, major adverse cardiac events (MACEs) were found in 50% patients, and the survival rate was 86.7%. We observed that the LVEF was significantly elevated after deployment (46.00 ± 6.00% vs. 35.83 ± 1.47%, P = 0.009). Besides, the LVEDD elevated after MI (51.17 ± 3.71 vs. 62.83 ± 3.25, P < 0.001) was revealed, but the device sustained preserved LVEDD after implantation.
      Conclusion: The PARACHUTE device is an alternative therapy for patients with severe LV maladaptive remodeling. However, the device seems to increase the HF ratio.
      Trial Registration: NCT02240940.
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    • Grant Information:
      A2018530 Natural Science Foundation of Guangdong Province; SZSM201412012 Sanming Project of Medicine in Shenzhen; szxk003 Shenzhen Key Medical Discipline Construction Fund; JCYJ20170307100512856 Science and Technology Planning Project of Shenzhen Municipality; 81770496 National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: Heart failure; Left ventricular systolic function; Mortality; Myocardial infarction
    • Molecular Sequence:
      ClinicalTrials.gov NCT02240940
    • Publication Date:
      Date Created: 20210421 Date Completed: 20210621 Latest Revision: 20210621
    • Publication Date:
      20221213
    • Accession Number:
      PMC8056655
    • Accession Number:
      10.1186/s13019-021-01484-0
    • Accession Number:
      33879206