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Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
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- Author(s): Bai X;Bai X; Fu R; Duan Z; Liu Y; Zhu C; Fan D
- Source:
Food & function [Food Funct] 2021 Apr 07; Vol. 12 (7), pp. 2874-2885. Date of Electronic Publication: 2021 Mar 19.
- Publication Type:
Journal Article
- Language:
English
- Additional Information
- Source:
Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE
- Publication Information:
Original Publication: Cambridge : Royal Society of Chemistry
- Subject Terms:
- Abstract:
Ginsenoside Rh4, as a bioactive component obtained from Panax notoginseng, has excellent pharmacological properties. However, its role in regulating gut microbiota and intestinal inflammation is still poorly understood. Thus, the aim of this study is to investigate the effect of Rh4 on gut microbiota, especially antibiotic-induced microbiota perturbation, and the underlying mechanisms. C57BL/6 mice were given different doses of Rh4 after the establishment of a gut microbiota disturbance model with antibiotics. Our data revealed that Rh4 administration could greatly improve the pathological phenotype, gut barrier disruption, and intestinal inflammation in mice that had been antibiotic-induced. Notably, it was found that Rh4 significantly inhibited the TLR4-MyD88-MAPK signaling pathway. In addition, Rh4 treatment could significantly increase the number of short chain fatty acids (SCFAs) and bile acids (BAs). These changes were accompanied with beneficial alterations in gut microbiota diversity and composition. In conclusion, Rh4 improves intestinal inflammation and induces potentially beneficial changes in the gut microbiota, which are conducive to revealing host-microbe interactions.
- Accession Number:
0 (Anti-Bacterial Agents)
0 (Cytokines)
0 (Fatty Acids, Volatile)
0 (Ginsenosides)
0 (Myd88 protein, mouse)
0 (Myeloid Differentiation Factor 88)
0 (Tlr4 protein, mouse)
0 (Toll-Like Receptor 4)
0 (ginsenoside Rh4)
EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
- Publication Date:
Date Created: 20210420 Date Completed: 20210528 Latest Revision: 20210528
- Publication Date:
20240829
- Accession Number:
10.1039/d1fo00242b
- Accession Number:
33877243
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