Persistent Somatic Symptom Burden and Sleep Disturbance in Patients with COVID-19 During Hospitalization and After Discharge: A Prospective Cohort Study.

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  • Additional Information
    • Source:
      Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 9609063 Publication Model: Electronic Cited Medium: Internet ISSN: 1643-3750 (Electronic) Linking ISSN: 12341010 NLM ISO Abbreviation: Med Sci Monit Subsets: MEDLINE
    • Publication Information:
      Publication: 2014- : Smithtown, NY : International Scientific Information, Inc.
      Original Publication: Warsaw, Poland : Medical Science International
    • Subject Terms:
      Cost of Illness* ; Medically Unexplained Symptoms*; COVID-19/*complications ; Myalgia/*epidemiology ; Sleep Wake Disorders/*epidemiology; Adult ; Aged ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; China/epidemiology ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Myalgia/diagnosis ; Myalgia/etiology ; Myalgia/physiopathology ; Patient Admission/statistics & numerical data ; Patient Discharge/statistics & numerical data ; Prognosis ; Prospective Studies ; Quarantine/statistics & numerical data ; Risk Assessment/statistics & numerical data ; SARS-CoV-2/isolation & purification ; Self Report/statistics & numerical data ; Severity of Illness Index ; Sleep/physiology ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/etiology
    • Abstract:
      BACKGROUND The present study was designed to reveal the trajectory of self-reported somatic symptom burden and sleep quality over time in patients with COVID-19 and to identify prognostic factors for greater somatic symptom burden and sleep disturbance. MATERIAL AND METHODS Seventy-four patients with COVID-19 were prospectively followed for longitudinal assessment of somatic symptom burden and sleep quality. We used the 8-item Somatic Symptom Scale (SSS-8) and the modified Medical Research Council (mMRC) scale for somatic symptom burden and the Pittsburgh Sleep Quality Index for sleep quality investigation. Univariate and multivariate analyses were performed to identify independent factors associated with somatic symptom burden and sleep quality. RESULTS Although the degree of physical discomfort and sleep quality issues tended to decline during self-quarantine, patients still experienced these problems to a certain degree. Univariate and multivariate analyses showed that SSS-8 scores at admission (relative risk [RR] 1.234, 95% CI 1.075-1.417, P=0.003) and mMRC scores at discharge (RR 2.420, 95% CI 1.251-4.682, P=0.009) were 2 independent prognostic indicators of somatic symptom burden. In addition, muscle pain as a chief complaint (RR 4.682, 95% CI 1.247-17.580, P<0.022) and history of use of hypnotic drugs (RR 0.148, 95% CI 0.029-0.749, P<0.019) were 2 independent indicators of patient sleep quality during hospitalization. CONCLUSIONS To the best of our knowledge, the present study was the first dynamic assessment of the somatic symptom burden and sleep quality in patients with COVID-19 during hospitalization and quarantine after discharge. Patients with high somatic symptom burden at admission, especially muscle pain as the chief complaint, are prone to having a higher physical burden and more sleep disturbance at discharge.
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    • Publication Date:
      Date Created: 20210415 Date Completed: 20210420 Latest Revision: 20240401
    • Publication Date:
      20240401
    • Accession Number:
      PMC8057653
    • Accession Number:
      10.12659/MSM.930447
    • Accession Number:
      33854028