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Effects of Dietary Supplementation with Myo-inositol on Hepatic Expression of Glycolytic and Fructolytic Enzyme Genes in Rats Fed a High-sucrose Diet.
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- Additional Information
- Source:
Publisher: Japan Oil Chemists' Society Country of Publication: Japan NLM ID: 101175339 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-3352 (Electronic) Linking ISSN: 13458957 NLM ISO Abbreviation: J Oleo Sci Subsets: MEDLINE
- Publication Information:
Original Publication: Tokyo : Japan Oil Chemists' Society
- Subject Terms:
- Abstract:
We examined effects of a major lipotrope, myo-inositol, on the expression of primary glycolytic (glucokinase and phosphofructokinase) and fructolytic enzyme (ketohexokinase [KHK] and aldolase B) genes in the livers of rats fed a control diet, high-sucrose diet, or high-sucrose diet supplemented with 0.5% myo-inositol for 14 d. Supplementation with myo-inositol decreased the hepatic expression of fructolytic enzyme genes, but not that of glycolytic enzyme genes, and the levels of triglycerides, fatty acid synthase, and KHK proteins in high-sucrose diet-induced fatty liver. The study results suggest that myo-inositol represses primary fructlysis, but not glycolysis, in high-sucrose diet-induced fatty liver.
- Contributed Indexing:
Keywords: KHK; liver; myo-inositol; rats; sucrose
- Accession Number:
0 (Dietary Sucrose)
4L6452S749 (Inositol)
EC 2.7.1 - (Phosphofructokinases)
EC 2.7.1.- (Fructokinases)
EC 2.7.1.2 (Glucokinase)
EC 2.7.1.3 (ketohexokinase)
EC 4.1.2.13 (Fructose-Bisphosphate Aldolase)
- Publication Date:
Date Created: 20210412 Date Completed: 20211020 Latest Revision: 20240226
- Publication Date:
20240226
- Accession Number:
10.5650/jos.ess20340
- Accession Number:
33840666
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