Survival following surgical treatment for anorectal melanoma seems similar for local excision and extensive resection regardless of nodal involvement.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9208188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3320 (Electronic) Linking ISSN: 09607404 NLM ISO Abbreviation: Surg Oncol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier Science
      Original Publication: Oxford ; Boston : Blackwell Scientific Publications, c1992-
    • Subject Terms:
      Proctectomy*; Anus Neoplasms/*mortality ; Anus Neoplasms/*surgery ; Melanoma/*mortality ; Melanoma/*surgery; Aged ; Anus Neoplasms/pathology ; Female ; Humans ; Lymphatic Metastasis ; Male ; Melanoma/pathology ; Middle Aged ; Netherlands ; Registries ; Retrospective Studies ; Survival Rate ; Time-to-Treatment ; Treatment Outcome
    • Abstract:
      Background: Anorectal melanoma is a rare malignancy with a dismal prognosis. The purpose of this study was to investigate whether the survival per stage is influenced by the surgical approaches (local excision or extensive resection), to assess prognostic factors of survival, and to answer the question whether the practiced surgical approaches changed over time.
      Methods: Dutch cancer registry organizations (IKNL and PALGA) were queried for all patients with a diagnosis of anorectal melanoma (1989-2019). Patients with disseminated disease at diagnosis were excluded. Survival outcomes were compared for the two surgical approaches stratified by stage (clinical node negative (cN0) and clinical node positive (cN+)) and date of diagnosis.
      Results: A total of 103 patients were included in this study. In both cN0 and cN+ patients the surgical strategy did not significantly influence survival (cN0: 21.7% 5-year survival, median 25 months for local excision versus 13.7% 5-year survival, median 17 months for extensive resection (p = 0.228), cN+: 11.1% 5-year survival for local excision, median 17 months versus 8.7% 5-year survival, median 14 months for extensive resection (p = 0.741)). Stage and date of diagnosis showed to be prognostic factors of survival. The ratio between the two surgical approaches was unchanged over three decades.
      Conclusions: Extensive resection does not seem to improve survival in both cN0 and cN+ anorectal melanoma patients compared to local excision. However in the past three decades no shift towards local excision has been found. cN+ stage and an older date of diagnosis are predictors for worse survival.
      (Copyright © 2021 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Abdominoperineal resection; Anorectal melanoma; Local excision; Staging; Surgery
    • Publication Date:
      Date Created: 20210411 Date Completed: 20211228 Latest Revision: 20211228
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.suronc.2021.101558
    • Accession Number:
      33839445