Herbal Medicine and Acupuncture Combined Treatment Attenuates Colitis in Rats.

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  • Additional Information
    • Source:
      Publisher: World Scientific Pub Country of Publication: Singapore NLM ID: 7901431 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1793-6853 (Electronic) Linking ISSN: 0192415X NLM ISO Abbreviation: Am J Chin Med Subsets: MEDLINE
    • Publication Information:
      Publication: <2003->: Singapore ; River Edge, NJ : World Scientific Pub.
      Original Publication: [Garden City, N.Y.] : Institute for Advanced Research in Asian Science and Medicine
    • Subject Terms:
      Acupuncture Therapy/*methods ; Colitis/*therapy ; Herbal Medicine/*methods ; Inflammation/*drug therapy; Animals ; Combined Modality Therapy ; Dextran Sulfate ; Disease Models, Animal ; Male ; Rats ; Rats, Sprague-Dawley
    • Abstract:
      This study aimed to verify the efficacy of a combined treatment of Jakyakgamcho-tang (JGT) and acupuncture (CV12, ST25, CV4) on colitis induced by dextrane sulfate sodium (DSS). Changes in immuno-mediated factors and metabolites were investigated. Colitis symptoms such as body weight loss and elevated disease activity index were alleviated by the combined treatment. Moreover, treatment with JGT and acupuncture restored the disturbed architecture of colon by suppressing inflammatory cytokine levels of IFN-[Formula: see text] ([Formula: see text] < 0.05), IL-5 ([Formula: see text] < 0.05), and IL-13 ([Formula: see text] < 0.0001) compared with the DSS group. Analysis of metabolic profiles of serum revealed that treatment groups were clearly separated from the DSS group, suggesting that JGT and acupuncture treatment altered serum metabolites. Furthermore, treatments caused opposite metabolite patterns for dimethylbenzimidazole, 1,5-anhydro-D-glucitol, proline, phosphate, glycolic acid, aspartic acid, tryptophan, phthalic acid, ornithine, and glutamic acid compared with the DSS group. The combined treatment group induced more effective metabolite patterns than the JGT group, implying that acupuncture treatment can restore metabolic changes caused by DSS induction. These results indicate that the simultaneous treatment of JGT administration and acupuncture procedure provides better management of the immune function and inflammatory expression of colitis than a single treatment. It is assumed that intestinal microbial control can be achieved by acupuncture stimulation as well as by taking herbal medicine.
    • Contributed Indexing:
      Keywords: Acupuncture; Colitis; Combined Treatment; Herbal Medicine; Immune Function; Inflammatory Bowel Disease; Metabolite
    • Accession Number:
      9042-14-2 (Dextran Sulfate)
    • Publication Date:
      Date Created: 20210408 Date Completed: 20210924 Latest Revision: 20210924
    • Publication Date:
      20231215
    • Accession Number:
      10.1142/S0192415X21500464
    • Accession Number:
      33827383