Vaccines and allergic reactions: The past, the current COVID-19 pandemic, and future perspectives.

Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1398-9995 (Electronic) Linking ISSN: 01054538 NLM ISO Abbreviation: Allergy Subsets: MEDLINE

Publication: Copenhagen : Wiley-Blackwell
Original Publication: Copenhagen, Munksgaard.

COVID-19* ; Hypersensitivity*/diagnosis ; Hypersensitivity*/epidemiology ; Hypersensitivity*/etiology ; Vaccines*/adverse effects; COVID-19 Vaccines ; Humans ; Pandemics ; SARS-CoV-2

Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.
(© 2021 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

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Keywords: COVID-19; SARS-CoV-2; allergy; anaphylaxis; vaccine

0 (COVID-19 Vaccines)
0 (Vaccines)

Date Created: 20210403 Date Completed: 20210618 Latest Revision: 20231107

20240829

PMC8251022

10.1111/all.14840

33811364