Effects of Christian Orthodox Fasting Versus Time-Restricted Eating on Plasma Irisin Concentrations Among Overweight Metabolically Healthy Individuals.

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  • Additional Information
    • Source:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • Subject Terms:
      Religion*; Diet/*methods ; Fasting/*blood ; Fibronectins/*blood ; Overweight/*blood; Female ; Greece ; Humans ; Male ; Middle Aged ; Pilot Projects ; Time
    • Abstract:
      Irisin has been recently identified as an adipomyokine produced during physical activity and involved in the browning of adipose tissue. Despite the emerging evidence suggesting an inverse relationship between irisin plasma concentrations and adverse metabolic outcomes, the exact impact of diet on irisin levels remains obscure. Thus, we aimed to assess the effects of two dietary patterns, Christian Orthodox fasting (OF) and 16:8 time-restricted eating (TRE), on circulating irisin levels among overweight, metabolically healthy, adults. Plasma irisin, glucose and lipid parameters, calcium homeostasis, and anthropometry were evaluated in 29 Orthodox fasters and 14 age and body mass index (BMI)-matched TRE controls (mean age and BMI, 48.8 years and 28.7 kg/m 2 , respectively) at three, distinct time points-before the implementation of the energy-restricted diets (baseline), at the end of the dietary intervention (7 weeks) and 5 weeks after participants returned to their typical dietary habits (12 weeks from baseline). Repeated measures analysis was applied to assess differences between the two groups and the effect of several indices on irisin levels at all three time points. At 12 weeks, the OF group manifested higher irisin concentrations compared with both its baseline values (64.3 ± 54.4 vs. 43.6 ± 42.2 ng/mL, p = 0.01) and those of the TRE group at the same time point (64.3 ± 54.4 vs. 44.2 ± 26.6 ng/mL, p = 0.04). Glycemic, lipid, and anthropometric parameters were not found to correlate with irisin levels. In contrast, parathyroid hormone (PTH) concentrations at 12 weeks correlated with irisin concentrations ( p = 0.04), indicating that lower values of irisin are expected for higher PTH measurements. The findings of this pilot study suggest favorable long-term effects of OF on irisin levels. The interplay between irisin, PTH, and diet warrants further investigation.
    • References:
      Nutrients. 2021 Feb 15;13(2):. (PMID: 33671993)
      J Clin Endocrinol Metab. 2019 Aug 1;104(8):3088-3096. (PMID: 30759249)
      PLoS One. 2017 Jan 26;12(1):e0170690. (PMID: 28125733)
      Circulation. 2014 Jun 24;129(25 Suppl 2):S102-38. (PMID: 24222017)
      Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E369-E380. (PMID: 28143856)
      Nutr Rev. 2015 Oct;73(10):661-74. (PMID: 26374764)
      Eur J Clin Nutr. 2018 Apr;72(4):474-479. (PMID: 29453427)
      Eur J Clin Nutr. 2014 Feb;68(2):259-64. (PMID: 24300904)
      J Clin Endocrinol Metab. 2014 Sep;99(9):3247-55. (PMID: 24915120)
      Obesity (Silver Spring). 2014 Jul;22(7):1701-8. (PMID: 24644099)
      PLoS One. 2013 Apr 11;8(4):e60563. (PMID: 23593248)
      Clin Nutr. 2016 Apr;35(2):484-490. (PMID: 25912185)
      Nutrients. 2020 Mar 11;12(3):. (PMID: 32168929)
      Nature. 2012 Jan 11;481(7382):463-8. (PMID: 22237023)
      Clin Endocrinol (Oxf). 2014 Aug;81(2):306-11. (PMID: 24325584)
      Am J Clin Nutr. 1990 Feb;51(2):241-7. (PMID: 2305711)
      Tohoku J Exp Med. 2014;233(2):135-40. (PMID: 24910199)
      Nutr Res. 2020 Mar;75:32-43. (PMID: 31955013)
      Nutrition. 2019 Mar;59:69-76. (PMID: 30423548)
      Prev Med. 2002 Apr;34(4):428-35. (PMID: 11914049)
      Clin Endocrinol (Oxf). 2015 Apr;82(4):615-9. (PMID: 25400208)
      Arch Dis Child. 2006 Jul;91(7):612-7. (PMID: 16790722)
      Eur J Nutr. 2017 Dec;56(8):2439-2455. (PMID: 28856433)
      Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12157-62. (PMID: 26374841)
      Metabolism. 2016 Jun;65(6):825-34. (PMID: 27173461)
      Physiol Res. 2016 Jun 20;65(2):271-9. (PMID: 26447516)
      Nutr Rev. 2014 May;72(5):308-18. (PMID: 24739093)
      Front Endocrinol (Lausanne). 2019 Aug 02;10:524. (PMID: 31428053)
      Eur J Clin Nutr. 2017 Jun;71(6):743-749. (PMID: 28327563)
      Int J Food Sci Nutr. 2021 Mar;72(2):248-258. (PMID: 32605472)
      Int J Food Sci Nutr. 2021 Feb;72(1):82-92. (PMID: 32362210)
      Nutrition. 2017 Mar;35:14-20. (PMID: 28241983)
      Nutrients. 2018 Jun 28;10(7):. (PMID: 29958455)
      Appetite. 2015 Jul;90:154-9. (PMID: 25765248)
      Osteoporos Int. 2014 May;25(5):1633-42. (PMID: 24599275)
    • Grant Information:
      1395/2019 Hellenic Diabetes Association
    • Contributed Indexing:
      Keywords: Orthodox fasting; cardiometabolic health; irisin; time-restricted eating
    • Accession Number:
      0 (Fibronectins)
    • Publication Date:
      Date Created: 20210403 Date Completed: 20210524 Latest Revision: 20210524
    • Publication Date:
      20221213
    • Accession Number:
      PMC8064431
    • Accession Number:
      10.3390/nu13041071
    • Accession Number:
      33806150