Neutrophil-to-lymphocyte Ratio as a Predictor of Malignancy of Intraductal Papillary Mucinous Neoplasms.

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  • Additional Information
    • Source:
      Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Internet ISSN: 1791-7530 (Electronic) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE
    • Publication Information:
      Publication: Attiki, Greece : International Institute of Anticancer Research
      Original Publication: Athens, Greece : Potamitis Press
    • Subject Terms:
      Lymphocytes* ; Neutrophils*; Pancreatic Intraductal Neoplasms/*pathology ; Pancreatic Neoplasms/*pathology; Aged ; Biomarkers, Tumor ; Female ; Humans ; Male ; Neoplasm Grading ; Pancreatic Intraductal Neoplasms/immunology ; Pancreatic Intraductal Neoplasms/mortality ; Pancreatic Intraductal Neoplasms/surgery ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/surgery ; Retrospective Studies
    • Abstract:
      Background: Intraductal papillary mucinous neoplasm (IPMN) can lead, via the adenoma-carcinoma sequence, to invasive adenocarcinoma, which has a poor prognosis. Most IPMNs do not meet the indications for surgery and instead are monitored regularly, but no biomarkers of malignant transformation during surveillance have been established.
      Patients and Methods: A total of 50 patients with IPMN who underwent pancreatectomy were evaluated retrospectively. Clinicopathological parameters during the surveillance period before surgery were assessed to explore biomarkers for predicting malignancy.
      Results: The serum level of carbohydrate antigen 19-9 was significantly higher in IPMN-derived invasive adenocarcinoma. The neutrophil-to-lymphocyte ratio was significantly lower in low-grade IPMN than high-grade and Inv-IPMN cases by univariate and multivariate analysis. Disease-free survival was significantly shorter in patients with high-grade and invasive IPMN compared with those with low-grade IPMN. In patients whose preoperative surveillance was performed for more than 12 months, the neutrophil-to-lymphocyte ratio was significantly higher in those with high-grade and invasive IPMNs compared with patients with low-grade IPMN in the year before surgery.
      Conclusion: The NLR is a useful biomarker for distinguishing between low-grade and high-grade IPMN and thus should be monitored during surveillance.
      (Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
    • Contributed Indexing:
      Keywords: Neutrophil-to-lymphocyte ratio; adenocarcinoma; intraductal papillary mucinous neoplasm; surveillance
    • Accession Number:
      0 (Biomarkers, Tumor)
    • Publication Date:
      Date Created: 20210331 Date Completed: 20210408 Latest Revision: 20210408
    • Publication Date:
      20240829
    • Accession Number:
      10.21873/anticanres.14929
    • Accession Number:
      33788763