Individualization of the infusion rate of a soybean oil-based intravenous lipid emulsion for inpatients, based on baseline triglyceride concentrations: A population pharmacokinetic approach.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: United States NLM ID: 7804134 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-2444 (Electronic) Linking ISSN: 01486071 NLM ISO Abbreviation: JPEN J Parenter Enteral Nutr Subsets: MEDLINE
    • Publication Information:
      Publication: 2018- : [Hoboken, NJ] : Wiley
      Original Publication: Thorofare, N. J., Slack.
    • Subject Terms:
      Fat Emulsions, Intravenous* ; Soybean Oil*; Humans ; Inpatients ; Kinetics ; Triglycerides
    • Abstract:
      Background: A rapid infusion rate for intravenous lipid emulsion (ILE) can cause adverse effects; therefore, safe and efficient infusion rates are desired. This study aimed to develop a triglyceride (TG) kinetic model after soybean oil-based ILE (SO-ILE) administration and individualize the infusion rate via a population pharmacokinetic approach.
      Methods: Eighty-three inpatients were enrolled in this prospective observational study. A TG kinetic model was applied to the observations based on population pharmacokinetics using a nonlinear mixed-effect model. The patients' characteristics and laboratory parameters were evaluated to identify predictors of TG kinetics, and the maximum acceptable infusion rate was defined as that for which the maximum TG concentration did not exceed 400 mg/dl in 90% of patients.
      Results: No adverse events associated with SO-ILE administration were observed. The developed TG kinetic model explained the observed TG concentrations and identified the baseline TG concentration and body weight as predictors of TG kinetics. The estimated maximum acceptable infusion rates greatly varied among individuals, ranging from <0.01 to 0.3 g/kg/h.
      Conclusion: The present study suggested the necessity and demonstrated the feasibility of individualizing the infusion rates of SO-ILE, using a population pharmacokinetic approach.
      (© 2021 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition.)
    • References:
      JPEN J Parenter Enteral Nutr. 1994 Sep-Oct;18(5):396-7. (PMID: 7815668)
      J Clin Lipidol. 2016 Sep-Oct;10(5):1163-71. (PMID: 27678433)
      Clin Nutr. 2009 Aug;28(4):387-400. (PMID: 19505748)
      Clin Toxicol (Phila). 2016 Jun;54(5):365-404. (PMID: 27035513)
      Diabetes Res Clin Pract. 2007 Apr;76(1):93-101. (PMID: 16956692)
      Ger Med Sci. 2009 Nov 18;7:Doc22. (PMID: 20049078)
      Ann Nutr Metab. 2006;50(3):253-9. (PMID: 16508253)
      Atherosclerosis. 1978 Sep;31(1):59-64. (PMID: 708498)
      J Clin Endocrinol Metab. 2016 Nov;101(11):4151-4160. (PMID: 27588438)
      JPEN J Parenter Enteral Nutr. 2009 May-Jun;33(3):277-316. (PMID: 19398613)
      JPEN J Parenter Enteral Nutr. 2009 Sep-Oct;33(5):501-12. (PMID: 19420283)
      Intensive Care Med. 2001 May;27(5):925-9. (PMID: 11430552)
      J Clin Invest. 1985 Feb;75(2):384-90. (PMID: 3973011)
      JPEN J Parenter Enteral Nutr. 2014 Jan;38(1):119-21. (PMID: 23520135)
      JPEN J Parenter Enteral Nutr. 2017 Nov;41(8):1356-1365. (PMID: 27466263)
      JPEN J Parenter Enteral Nutr. 1985 Jul-Aug;9(4):461-3. (PMID: 4032683)
      J Med Toxicol. 2014 Mar;10(1):10-4. (PMID: 24338451)
      JPEN J Parenter Enteral Nutr. 2010 Jul-Aug;34(4):387-94. (PMID: 20631384)
      JPEN J Parenter Enteral Nutr. 2015 Sep;39(1 Suppl):33S-8S. (PMID: 26177663)
      Crit Care. 2015 May 12;19:226. (PMID: 25962383)
      AAPS J. 2011 Jun;13(2):143-51. (PMID: 21302010)
      Nutrition. 1996 Feb;12(2):79-82. (PMID: 8724376)
      Clin Infect Dis. 2011 May;52(9):e162-93. (PMID: 21460264)
      J Infus Nurs. 2016 Nov/Dec;39(6):377-380. (PMID: 27828934)
      World Rev Nutr Diet. 2015;112:17-30. (PMID: 25471799)
      Biochemistry. 2003 Feb 25;42(7):1872-89. (PMID: 12590574)
      J Med Toxicol. 2012 Mar;8(1):10-4. (PMID: 21989640)
      Metabolism. 1979 May;28(5):495-501. (PMID: 449689)
      JPEN J Parenter Enteral Nutr. 2022 Jan;46(1):104-113. (PMID: 33769561)
    • Contributed Indexing:
      Keywords: infusion rate; intravenous lipid emulsion; population pharmacokinetics; triglyceride
    • Accession Number:
      0 (Fat Emulsions, Intravenous)
      0 (Triglycerides)
      8001-22-7 (Soybean Oil)
    • Publication Date:
      Date Created: 20210326 Date Completed: 20220331 Latest Revision: 20220731
    • Publication Date:
      20221213
    • Accession Number:
      PMC9290941
    • Accession Number:
      10.1002/jpen.2111
    • Accession Number:
      33769561