The effect of somatosensory alpha transcranial alternating current stimulation on pain empathy is trait empathy and gender dependent.

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  • Author(s): Wang P;Wang P; Zhu M; Zhu M; Mo S; Mo S; Li X; Li X; Wang J; Wang J
  • Source:
    CNS neuroscience & therapeutics [CNS Neurosci Ther] 2021 Jun; Vol. 27 (6), pp. 687-693. Date of Electronic Publication: 2021 Mar 19.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford, UK : Wiley-Blackwell, c2008-
    • Subject Terms:
      Alpha Rhythm* ; Transcranial Direct Current Stimulation*; Empathy/*physiology ; Evoked Potentials, Somatosensory/*physiology ; Pain/*psychology; Adolescent ; Adult ; Electroencephalography ; Female ; Humans ; Male ; Neuropsychological Tests ; Sex Characteristics ; Somatosensory Cortex/physiology ; Young Adult
    • Abstract:
      Background: Pain empathy enables a person to experience and understand other's pain state by observing others in pain condition. Such prosocial ability is deficient in many psychopathological disorders. Somatosensory alpha suppression is considered as neural correlates of pain empathy and is hypothesized as a target for enhancement of pain empathy. Researches demonstrated that alpha suppression could be enhanced by transcranial alternating current stimulation (tACS) at alpha frequency non-invasively.
      Aims: We applied alpha tACS over the primary somatosensory cortex of healthy subjects to investigate whether alpha tACS is able to enhance the pain empathy performance.
      Results: The results showed that there was no difference of pain empathy performance between alpha tACS and sham tACS either when tACS was applied during the task or before task. While in the alpha tACS group, the pain empathy performance was positively correlated with empathic concern of male subjects, the sub-component of personal trait empathy.
      Conclusions: Alpha tACS cannot alter the empathy performance overall, but the modulation effect of alpha tACS on pain empathy is dependent on the gender and trait empathy of subjects.
      (© 2021 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)
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    • Contributed Indexing:
      Keywords: Alpha ERD; empathy concern; pain empathy; transcranial alternating current stimulation
    • Publication Date:
      Date Created: 20210319 Date Completed: 20220131 Latest Revision: 20220131
    • Publication Date:
      20240829
    • Accession Number:
      PMC8111491
    • Accession Number:
      10.1111/cns.13631
    • Accession Number:
      33739605