The emotional face of anorexia nervosa: The neural correlates of emotional processing.

Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE

Publication: New York : Wiley
Original Publication: New York : Wiley-Liss, c1993-

Connectome* ; Social Perception*; Anorexia Nervosa/*physiopathology ; Cerebral Cortex/*physiopathology ; Emotions/*physiology ; Facial Recognition/*physiology; Adolescent ; Adult ; Anorexia Nervosa/diagnostic imaging ; Cerebral Cortex/diagnostic imaging ; Facial Expression ; Female ; Humans ; Magnetic Resonance Imaging ; Young Adult

Social-emotional processing difficulties have been reported in Anorexia Nervosa (AN), yet the neural correlates remain unclear. Previous neuroimaging work is sparse and has not used functional connectivity paradigms to more fully explore the neural correlates of emotional difficulties. Fifty-seven acutely unwell AN (AAN) women, 60 weight-recovered AN (WR) women and 69 healthy control (HC) women categorised the gender of a series of emotional faces while undergoing Functional Magnetic Resonance Imaging. The mean age of the AAN group was 19.40 (2.83), WR 18.37 (3.59) and HC 19.37 (3.36). A whole brain and psychophysical interaction connectivity approach was used. Parameter estimates from significant clusters were extracted and correlated with clinical symptoms. Whilst no group level differences in whole brain activation were demonstrated, significant group level functional connectivity differences emerged. WR participants showed increased connectivity between the bilateral occipital face area and the cingulate, precentral gyri, superior, middle, medial and inferior frontal gyri compared to AAN and HC when viewing happy valenced faces. Eating disorder symptoms and parameter estimates were positively correlated. Our findings characterise the neural basis of social-emotional processing in a large sample of individuals with AN.
(© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)

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MR/R004595/1 United Kingdom MRC_ Medical Research Council; MR/S020381/1 United Kingdom MRC_ Medical Research Council; United Kingdom DH_ Department of Health

Keywords: anorexia nervosa; emotional faces; emotional processing; functional magnetic resonance imagining; psychophysical interaction

Date Created: 20210319 Date Completed: 20220307 Latest Revision: 20220307

20231215

PMC8193512

10.1002/hbm.25417

33739540