Distinct burst properties contribute to the functional diversity of thalamic nuclei.

Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0406041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9861 (Electronic) Linking ISSN: 00219967 NLM ISO Abbreviation: J Comp Neurol Subsets: MEDLINE

Publication: <2003-> : Hoboken, N.J. : Wiley-Liss
Original Publication: Philadelphia Wistar Institute of Anatomy and Biology

Patch-Clamp Techniques*; Action Potentials/*physiology ; Neurons/*physiology ; Thalamic Nuclei/*physiology; Animals

Thalamic neurons fire spikes in two modes, burst and tonic. The function of burst firing is unclear, but the evidence suggests that bursts are more effective at activating cortical cells, and that postinhibition rebound bursting contributes to thalamocortical oscillations during sleep. Bursts are considered stereotyped signals; however, there is limited evidence regarding how burst properties compare across thalamic nuclei of different functional or anatomical organization. Here, we used whole-cell patch clamp recordings and compartmental modeling to investigate the properties of bursts in six sensory thalamic nuclei, to study the mechanisms that can lead to different burst properties, and to assess the implications of different burst properties for thalamocortical transmission and oscillatory functions. We found that bursts in higher-order cells on average had higher number of spikes and longer latency to the first spike. Additionally, burst features in first-order neurons were determined by sensory modality. Shifting the voltage-dependence and density of the T-channel conductance in a compartmental model replicates the burst properties from the intracellular recordings, pointing to molecular mechanisms that can generate burst diversity. Furthermore, the model predicts that bursts with higher number of spikes will drastically reduce the effectiveness of thalamocortical transmission. In addition, the latency to burst limited the rebound oscillatory frequency in modeled cells. These results demonstrate that burst properties vary according to the thalamocortical hierarchy and with sensory modality. The findings imply that, while in burst mode, thalamocortical transmission and firing frequency will be determined by the number of spikes and latency to burst.
(© 2021 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC.)

Erratum in: J Comp Neurol. 2022 May;530(7):1126. (PMID: 35338485)

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R01 DC008794 United States DC NIDCD NIH HHS; EY03038 United States NH NIH HHS; DC008794 United States NH NIH HHS; R01 EY003038 United States EY NEI NIH HHS

Keywords: burst; first order; higher order; oscillation; sensory; thalamocortical; thalamus

Date Created: 20210316 Date Completed: 20220321 Latest Revision: 20220326

20231215

PMC8440663

10.1002/cne.25141

33723858