Diethylhexyl phthalate (DEHP) regulates the proliferation and chemosensitivity of esophageal squamous cell carcinoma cells via regulation of PTEN.

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: Japan NLM ID: 8912329 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1749-0774 (Electronic) Linking ISSN: 09147470 NLM ISO Abbreviation: Hum Cell Subsets: MEDLINE
    • Publication Information:
      Publication: 2011- : Tokyo : Springer
      Original Publication: Tōkyō-to : Hito Saibō Kenkyūkai : Kanishobo, Shōwa 63-nen [1988]-
    • Subject Terms:
      Genes, Tumor Suppressor*; Antineoplastic Agents/*pharmacology ; Cell Proliferation/*drug effects ; Cisplatin/*pharmacology ; Diethylhexyl Phthalate/*adverse effects ; Endocrine Disruptors/*adverse effects ; Esophageal Neoplasms/*genetics ; Esophageal Neoplasms/*pathology ; Esophageal Squamous Cell Carcinoma/*genetics ; Esophageal Squamous Cell Carcinoma/*pathology ; Fluorouracil/*pharmacokinetics ; Gene Expression Regulation, Neoplastic/*drug effects ; PTEN Phosphohydrolase/*genetics ; PTEN Phosphohydrolase/*metabolism ; Transcription, Genetic/*drug effects; Cell Line, Tumor ; Disease Progression ; Drug Resistance, Neoplasm/drug effects ; Gene Expression/drug effects ; Humans ; Protein Binding ; Transcription Factor HES-1/genetics ; Transcription Factor HES-1/metabolism ; Transcription, Genetic/genetics
    • Abstract:
      As one of the most prevalent and deadly cancers worldwide, esophageal squamous cell carcinoma (ESCC) can be directly exposed to endocrine-disrupting chemical (EDC). As a potential EDC, diethylhexyl phthalate (DEHP) can trigger the development of various cancers, while the potential effect of DEHP on the ESCC progression was not clear. Our present study revealed that DEHP can trigger the proliferation of ESCC cells and decrease the cisplatin (CDDP) and fluorouracil (5-FU) sensitivity. Mechanistical studies indicated that DEHP can decrease the transcription of PTEN, a well-characterized tumor suppressor, in ESCC cells. Over expression of PTEN can reverse DEHP-regulated ESCC cell proliferation and chemosensitivity. Further, DEHP can increase the expression of HES-1, which can bind with the promoter of PTEN to inhibit its transcription. Collectively, DEHP can increase proliferation while decrease chemosensitivity of ESCC cells via regulation of HES-1/PTEN axis. Further, daily expression of DEHP may be a potent risk factor for ESCC development.
    • Comments:
      Erratum in: Hum Cell. 2021 Apr 15;:. (PMID: 33856651)
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    • Contributed Indexing:
      Keywords: DEHP; ESCC; HES-1; PTEN
    • Accession Number:
      0 (Antineoplastic Agents)
      0 (Endocrine Disruptors)
      0 (Transcription Factor HES-1)
      149348-15-2 (HES1 protein, human)
      C42K0PH13C (Diethylhexyl Phthalate)
      EC 3.1.3.67 (PTEN Phosphohydrolase)
      EC 3.1.3.67 (PTEN protein, human)
      Q20Q21Q62J (Cisplatin)
      U3P01618RT (Fluorouracil)
    • Publication Date:
      Date Created: 20210315 Date Completed: 20211108 Latest Revision: 20211108
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s13577-021-00519-x
    • Accession Number:
      33721218