Anti-inflammatory effects of diet and caloric restriction in metabolic syndrome.

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  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: Italy NLM ID: 7806594 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1720-8386 (Electronic) Linking ISSN: 03914097 NLM ISO Abbreviation: J Endocrinol Invest Subsets: MEDLINE
    • Publication Information:
      Publication: 2014- : Berlin : Springer
      Original Publication: Milano, Published for the Italian Society of Endocrinology by Editrice Kurtis.
    • Subject Terms:
      Metabolic Syndrome*/blood ; Metabolic Syndrome*/diagnosis ; Metabolic Syndrome*/diet therapy ; Metabolic Syndrome*/immunology; Cholesterol Ester Transfer Proteins/*blood ; Cholesterol, HDL/*blood ; Cholesterol, LDL/*blood ; Cytokines/*blood ; Triglycerides/*blood ; Weight Loss/*immunology; Anthropometry/methods ; Body Mass Index ; Caloric Restriction/methods ; Diet, Reducing/methods ; Female ; Humans ; Lipid Metabolism/physiology ; Male ; Middle Aged ; Treatment Outcome
    • Abstract:
      Background: Weight loss in patients with metabolic syndrome has positive effects on cardiovascular and type 2 diabetes risks, but its effects on peripheral cytokines and lipid profiles in patients are still unclear.
      Aim: To determine the effects of diet-induced weight loss on metabolic parameters, lipids and cytokine profiles.
      Methods: Eighteen adult males with metabolic syndrome (defined according to IDF 2009) and Body Mass Index (BMI) between 25 and 35 kg/m 2 were subjected to a balanced hypocaloric diet for 6 months to reach at least a 5% body weight loss.
      Results: After weight loss, a significant improvement in BMI, waist circumference, insulin, fasting blood glucose and HOMA-IR (homeostasis model assessment of insulin resistance) was observed. The analysis of LDL (low-density lipoprotein cholesterol) and HDL (high-density lipoprotein cholesterol) lipoproteins showed a change in their composition with a massive transfer of triacylglycerols from HDL to LDL. This was associated with a significant reduction in peripheral pro-inflammatory cytokines such as IL-6, TNF-α, IL-8 and MIP-1β, leading to an overall decreased inflammatory score. An interesting positive correlation was also observed among peripheral cytokines levels after diet and peripheral levels of CETP (cholesteryl ester transfer protein), an enzyme with a key role in lipid change.
      Conclusion: Weight loss through caloric restriction is associated with an improvement in peripheral lipid and cytokine profiles that may play a major role in improving cardiovascular risk.
      (© 2021. The Author(s).)
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    • Grant Information:
      Linea2 2019 Università degli Studi di Milano; EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research 2019 European Foundation for the Study of Diabetes; RF-2016-02362512 Ministero della Salute
    • Contributed Indexing:
      Keywords: Caloric restriction; Cholesteryl ester transfer protein; Lipids; Metabolic syndrome; Pro-inflammatory cytokines
    • Accession Number:
      0 (Cholesterol Ester Transfer Proteins)
      0 (Cholesterol, HDL)
      0 (Cholesterol, LDL)
      0 (Cytokines)
      0 (Triglycerides)
    • Publication Date:
      Date Created: 20210309 Date Completed: 20220207 Latest Revision: 20220218
    • Publication Date:
      20250114
    • Accession Number:
      PMC8502121
    • Accession Number:
      10.1007/s40618-021-01547-y
    • Accession Number:
      33686615