Primate extrastriate cortical area MST: a gateway between sensation and cognition.

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  • Author(s): Wild B;Wild B;Wild B; Treue S; Treue S; Treue S; Treue S; Treue S
  • Source:
    Journal of neurophysiology [J Neurophysiol] 2021 May 01; Vol. 125 (5), pp. 1851-1882. Date of Electronic Publication: 2021 Mar 03.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE
    • Publication Information:
      Publication: Bethesda Md : American Physiological Society
      Original Publication: Washington [etc.]
    • Subject Terms:
      Cognition/*physiology ; Macaca/*physiology ; Motion Perception/*physiology ; Sensation/*physiology ; Temporal Lobe/*physiology ; Visual Cortex/*physiology; Animals ; Humans ; Temporal Lobe/anatomy & histology ; Visual Cortex/anatomy & histology
    • Abstract:
      Primate visual cortex consists of dozens of distinct brain areas, each providing a highly specialized component to the sophisticated task of encoding the incoming sensory information and creating a representation of our visual environment that underlies our perception and action. One such area is the medial superior temporal cortex (MST), a motion-sensitive, direction-selective part of the primate visual cortex. It receives most of its input from the middle temporal (MT) area, but MST cells have larger receptive fields and respond to more complex motion patterns. The finding that MST cells are tuned for optic flow patterns has led to the suggestion that the area plays an important role in the perception of self-motion. This hypothesis has received further support from studies showing that some MST cells also respond selectively to vestibular cues. Furthermore, the area is part of a network that controls the planning and execution of smooth pursuit eye movements and its activity is modulated by cognitive factors, such as attention and working memory. This review of more than 90 studies focuses on providing clarity of the heterogeneous findings on MST in the macaque cortex and its putative homolog in the human cortex. From this analysis of the unique anatomical and functional position in the hierarchy of areas and processing steps in primate visual cortex, MST emerges as a gateway between perception, cognition, and action planning. Given this pivotal role, this area represents an ideal model system for the transition from sensation to cognition.
    • Contributed Indexing:
      Keywords: cognition; eye movements; macaque; visual cortex; visual motion
    • Publication Date:
      Date Created: 20210303 Date Completed: 20220110 Latest Revision: 20220110
    • Publication Date:
      20221213
    • Accession Number:
      10.1152/jn.00384.2020
    • Accession Number:
      33656951