Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients.

Publisher: Sage Publications Country of Publication: United States NLM ID: 9508125 Publication Model: Print Cited Medium: Internet ISSN: 1938-2723 (Electronic) Linking ISSN: 10760296 NLM ISO Abbreviation: Clin Appl Thromb Hemost Subsets: MEDLINE

Publication: Thousand Oaks, CA : Sage Publications
Original Publication: New York, N.Y. : Raven Press, c1995-

Adenosine Deaminase/*blood ; Biomarkers/*blood ; Diabetes Mellitus, Type 2/*blood ; Vascular Calcification/*blood; Female ; Humans ; Male ; Middle Aged

We investigated the association between serum adenosine deaminase and coronary artery calcification (CAC) in type 2 diabetes mellitus (T2DM) patients. The cross-sectional study included 459 patients with T2DM, the clinical and laboratory tests were performed, and all T2DM patients were separated into the 3 groups based on the tertile of serum adenosine deaminase levels. In the baseline data, the CAC score had statistically significant differences between the 3 groups (p < 0.001). Serum adenosine deaminase levels were positively correlated with CAC score in T2DM patients (r = 0.355, p < 0.001). The results of multiple linear regression analysis showed that serum adenosine deaminase was independent positively correlated with CAC score in T2DM patients (r = 0.255, p < 0.001). Receiver-operating characteristic curve analysis showed that area under curve was 0.750 to identify T2DM patients with CAC. Serum adenosine deaminase levels are correlated with CAC scores in T2DM patients, clinically, serum adenosine deaminase should be considered as an underlying marker to determine the severity of atherosclerosis in T2DM patients.

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Keywords: cardiovascular disease; coronary artery calcification; serum adenosine deaminase; type 2 diabetes mellitus

0 (Biomarkers)
EC 3.5.4.4 (Adenosine Deaminase)

Date Created: 20210302 Date Completed: 20211026 Latest Revision: 20211026

20240628

PMC7930648

10.1177/1076029621999722

33651650