Genomic epidemiology of COVID-19 in care homes in the east of England.

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  • Additional Information
    • Corporate Authors:
      COVID-19 Genomics Consortium UK
    • Source:
      Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
    • Subject Terms:
      Nursing Homes*; COVID-19/*epidemiology ; COVID-19/*transmission ; SARS-CoV-2/*genetics; Aged, 80 and over ; COVID-19/virology ; Disease Outbreaks ; England/epidemiology ; Female ; Humans ; Infectious Disease Transmission, Patient-to-Professional ; Infectious Disease Transmission, Professional-to-Patient ; Male ; Polymorphism, Single Nucleotide ; Sequence Analysis ; Time Factors
    • Abstract:
      COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data, 409 viral clusters within the 292 homes were identified, indicating two different patterns - outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission within care homes should be a key target for infection control to reduce COVID-19 mortality in this population.
      Competing Interests: WH, GT, ES, DA, CH, BW, LM, MH, AJ, MC, SP, LC, SC, FK, AY, GH, TF, MP, IG, YC, CB, SG, RA, EH, NB, MB, MS, DJ, IJ, AA, JS, CL, GD, SP, DK, IG No competing interests declared, MT I have received grant support from the Academy of Medical Sciences, the Health Foundation, and the NIHR Biomedical Research Centre. I have also received book royalties from Oxford University Press and honoraria from the Wellcome Sanger Institute
      (© 2021, Hamilton et al.)
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    • Grant Information:
      COG-UK MC-PC-19027 United Kingdom WT_ Wellcome Trust; Collabrative grant 204870/Z/16/Z United Kingdom WT_ Wellcome Trust; MR/N029399/1 United Kingdom MRC_ Medical Research Council; COG-UK MC-PC-19027 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; Clinician Scientist Fellowship United Kingdom AMS_ Academy of Medical Sciences; Clinician Scientist Fellowship to MET United Kingdom AMS_ Academy of Medical Sciences; Senior Fellowship 097997/Z/11/Z United Kingdom WT_ Wellcome Trust; COG-UK grant to SJP United Kingdom MRC_ Medical Research Council; MC_PC_19027 United Kingdom MRC_ Medical Research Council
    • Contributed Indexing:
      Keywords: COVID-19; SARS-CoV-2; epidemiology; genetics; genomics; global health; virus
    • Publication Date:
      Date Created: 20210302 Date Completed: 20210402 Latest Revision: 20240211
    • Publication Date:
      20240211
    • Accession Number:
      PMC7997667
    • Accession Number:
      10.7554/eLife.64618
    • Accession Number:
      33650490