Old Friends with Unexploited Perspectives: Current Advances in Mesenchymal Stem Cell-Based Therapies in Asthma.

Publisher: Springer Science+Business Media Country of Publication: United States NLM ID: 101752767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2629-3277 (Electronic) Linking ISSN: 26293277 NLM ISO Abbreviation: Stem Cell Rev Rep Subsets: MEDLINE

Publication: 2011- : [New York, NY] : Springer Science+Business Media
Original Publication: [Totowa, N.J.] : Humana Press, [2009]-

Asthma*/therapy ; Mesenchymal Stem Cell Transplantation* ; Mesenchymal Stem Cells*; Animals ; Disease Models, Animal ; Humans

Mesenchymal stem cells (MSCs) have a great regenerative and immunomodulatory potential that was successfully tested in numerous pre-clinical and clinical studies of various degenerative, hematological and inflammatory disorders. Over the last few decades, substantial immunoregulatory effects of MSC treatment were widely observed in different experimental models of asthma. Therefore, it is tempting to speculate that stem cell-based treatment could become an attractive means to better suppress asthmatic airway inflammation, especially in subjects resistant to currently available anti-inflammatory therapies. In this review, we discuss mechanisms accounting for potent immunosuppressive properties of MSCs and the rationale for their use in asthma. We describe in detail an intriguing interplay between MSCs and other crucial players in the immune system as well as lung microenvironment. Finally, we reveal the potential of MSCs in maintaining airway epithelial integrity and alleviating lung remodeling.
(© 2021. The Author(s).)

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Keywords: Asthma; Experimental asthma; Immune regulation; Mesenchymal stem cells; Stem cells

Date Created: 20210302 Date Completed: 20220303 Latest Revision: 20220727

20221213

PMC7919631

10.1007/s12015-021-10137-7

33649900