In silico screening and identification of deleterious missense SNPs along with their effects on CD-209 gene: An insight to CD-209 related-diseases.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Mutation, Missense* ; Polymorphism, Single Nucleotide*; Cell Adhesion Molecules/*genetics ; Computational Biology/*methods ; Lectins, C-Type/*genetics ; Receptors, Cell Surface/*genetics; Cell Adhesion Molecules/chemistry ; Computer Simulation ; Genetic Predisposition to Disease ; Humans ; Hydrogen Bonding ; Lectins, C-Type/chemistry ; Models, Molecular ; Protein Conformation ; Protein Stability ; Receptors, Cell Surface/chemistry ; Software
    • Abstract:
      DC-SIGN receptor articulated by macrophages and dendritic cells is encoded by CD209 gene and plays a role to activate and proliferate the T-lymphocytes in response of virus attack. The dysfunctional activity of DC-SIGN receptor because of missense SNPs can lead to cause dengue haemorrhage fever, HIV-1 infection etc. Out of 11 transcripts of CD209, all missense SNPs of canonical transcript were retrieved from Ensembl database and evaluated by their deleteriousness by using Polyphen-2, PMut, SIFT, MutPred, PROVEAN and PhD-SNP together with stimulation of its complete 3D structure. 10 nsSNPs were chosen depending on both the significance value of nsSNP and their prediction among SNPs evaluating servers which are based on different algorithms. Moreover, the position and native role of 10 nsSNPs in wild 3D model has been described which assist to acknowledge their importance. This study urges the researcher's community to experimentally validate these SNPs and their association in causing the diseases like dengue fever, Tuberculosis etc.
      Competing Interests: The authors have declared that no competing interests exist.
    • Comments:
      Erratum in: PLoS One. 2022 Jul 5;17(7):e0271144. (PMID: 35789219)
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    • Accession Number:
      0 (Cell Adhesion Molecules)
      0 (DC-specific ICAM-3 grabbing nonintegrin)
      0 (Lectins, C-Type)
      0 (Receptors, Cell Surface)
    • Publication Date:
      Date Created: 20210226 Date Completed: 20210820 Latest Revision: 20220705
    • Publication Date:
      20231215
    • Accession Number:
      PMC7909662
    • Accession Number:
      10.1371/journal.pone.0247249
    • Accession Number:
      33635927