The dosimetry evaluation of 3D printing non-coplanar template-assisted CT-guided 125I seed stereotactic ablation brachytherapy for pelvic recurrent rectal cancer after external beam radiotherapy.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0376611 Publication Model: Print Cited Medium: Internet ISSN: 1349-9157 (Electronic) Linking ISSN: 04493060 NLM ISO Abbreviation: J Radiat Res Subsets: MEDLINE
    • Publication Information:
      Publication: July 2012- : Oxford : Oxford University Press
      Original Publication: Tokyo : Japan Radiation Research Society
    • Subject Terms:
      Brachytherapy*/adverse effects ; Printing, Three-Dimensional* ; Radiometry* ; Radiosurgery*/adverse effects ; Tomography, X-Ray Computed*; Iodine Radioisotopes/*chemistry ; Rectal Neoplasms/*radiotherapy ; Rectal Neoplasms/*surgery; Aged ; Dose-Response Relationship, Radiation ; Female ; Humans ; Male ; Middle Aged ; Pelvis/diagnostic imaging ; Pelvis/pathology ; Radiotherapy Dosage ; Rectal Neoplasms/diagnostic imaging
    • Abstract:
      The aim of this study was to investigate the safety and accuracy of computed tomography (CT)-guided 125I seed implantation assisted by a three-dimensional printing non-coplanar template (3D-PNCT) for treating pelvic locally recurrent rectal cancer (LRRC) patients. A total of 13 patients with 18 masses received 125I seed implantation. The dosimetric parameters of pre-implantation and post-implantation were calculated to evaluate the quality of 125I seed implantation. Doses delivered to the organs at risk (OAR) were also calculated. Differences between pre-implantation and post-implantation were compared by the paired t-test. The mean number of 125I seeds pre-implantation and post-implantation was 67.1 and 68.8, respectively. The mean values of D90 (dose that was delivered to 90% of the target volume), D100 (dose that was delivered to 100% of the target volume), V100 (the target volume receiving 100% of the prescription dose) and V150 (the target volume receiving 150% of the prescription dose) pre-implantation and post-implantation were 136.6 and 135.2 Gy, 63.5 and 71.0 Gy, 90.3% and 90.3% and 62.1% and 62.2%, respectively. Dosimetric outcomes were evaluated quantitatively using the dose volume indices, i.e. coverage index (CI), external volume index (EI) and relative dose homogeneity index (HI). The mean values of those indices pre-implantation and post-implantation were 0.62 and 0.61, 0.31 and 0.33, and 0.31 and 0.31, respectively. The mean doses delivered to OAR pre-implantation and post-implantation for the bladder (D2cc) and bowel (D2cc) were 33.4 and 34.4 Gy, and 58.6 and 61.8 Gy, respectively. The parameters mentioned above fitted well, and no significant difference was found among them. It is concluded that CT-guided 125I seed implantation assisted by 3D-PNCT could be a safe and accurate salvage modality for treating LRRC patients; the ideal pre-prescription dose could be achieved. Also, addition of 3D-PNCT could minimize radiation damage to the surrounding normal tissues.
      (© The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.)
    • References:
      Int J Colorectal Dis. 2009 Apr;24(4):391-9. (PMID: 19084969)
      Zhonghua Kou Qiang Yi Xue Za Zhi. 2014 Feb;49(2):115-8. (PMID: 24731425)
      Int J Colorectal Dis. 2015 Aug;30(8):1075-80. (PMID: 26077667)
      Eur J Surg Oncol. 2001 Jun;27(4):349-53. (PMID: 11417978)
      J Radiat Res. 2012 Nov 1;53(6):973-7. (PMID: 22859564)
      Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):638-645. (PMID: 30391521)
      Med Oncol. 2010 Jun;27(2):421-9. (PMID: 19415534)
      Ann Surg. 2016 Aug;264(2):323-9. (PMID: 26692078)
      Appl Radiat Isot. 2017 Jun;124:68-74. (PMID: 28342381)
      J Radiat Res. 2016 Nov;57(6):662-667. (PMID: 27422928)
      Int J Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1267-74. (PMID: 11286833)
      World J Surg Oncol. 2013 Mar 08;11:60. (PMID: 23496973)
      Radiother Oncol. 2014 Nov;113(2):151-7. (PMID: 25613395)
      Colorectal Dis. 2011 Jul;13(7):732-42. (PMID: 20041928)
      Cancer Invest. 2012 Mar;30(3):236-42. (PMID: 22360363)
      J Natl Compr Canc Netw. 2019 Sep 1;17(9):1109-1133. (PMID: 31487687)
      Acta Oncol. 2014 Jul;53(7):865-76. (PMID: 24678823)
      Head Neck. 2014 Dec;36(12):E125-8. (PMID: 24585519)
    • Contributed Indexing:
      Keywords: 125I seed implantation; 3D printing non-coplanar template; CT guidance; dosimetric evaluation; pelvic locally recurrent rectal cancer; stereotactic ablation brachytherapy
    • Accession Number:
      0 (Iodine Radioisotopes)
      GVO776611R (Iodine-125)
    • Publication Date:
      Date Created: 20210222 Date Completed: 20211125 Latest Revision: 20240402
    • Publication Date:
      20240402
    • Accession Number:
      PMC8127672
    • Accession Number:
      10.1093/jrr/rraa144
    • Accession Number:
      33616168