Patient-Reported Outcomes of Split-Thickness Skin Grafts for Floor of Mouth Cancer Reconstruction.

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  • Additional Information
    • Source:
      Publisher: Karger Country of Publication: Switzerland NLM ID: 0334721 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0275 (Electronic) Linking ISSN: 03011569 NLM ISO Abbreviation: ORL J Otorhinolaryngol Relat Spec Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, New York, Karger.
    • Subject Terms:
      Mouth Neoplasms*/surgery ; Quality of Life*; Cross-Sectional Studies ; Humans ; Mouth Floor ; Patient Reported Outcome Measures
    • Abstract:
      Introduction: Patient-reported outcome measures (PROM) on quality of life (QOL) for early-stage floor of mouth carcinoma (FOM-CA) undergoing surgical resection and split-thickness skin graft (STSG) reconstruction have not been established. We have performed a cross-sectional QOL analysis of such patients to define functional postoperative outcomes.
      Methods: Patients with pathologic stage T1/T2 FOM-CA who underwent resection and STSG reconstruction at a tertiary academic cancer center reported outcomes with the University of Washington QOL (v4) questionnaire after at least 6 months since surgery.
      Results: Twenty-four out of 49 eligible patients completed questionnaires with a mean follow-up of 41 months (range: 6-88). Subsites of tumor involvement/resection included the following: (1) lateral FOM (L-FOM) (n = 17), (2) anterior FOM (A-FOM) (n = 4), and (3) alveolar ridge with FOM, all of whom underwent lateral marginal mandibulectomy (MM-FOM) (n = 3). All patients reported swallowing scores of 70 ("I cannot swallow certain solid foods") or better. Ninety-six percent (23/24) reported speech of 70 ("difficulty saying some words, but I can be understood over the phone") or better. A-FOM patients reported worse chewing than L-FOM patients (mean: 50.0 vs. 85.3; p = 0.01). All 4 A-FOM patients reported a low chewing score of 50 ("I can eat soft solids but cannot chew some foods"). Otherwise, there were no significant differences between subsite groups in swallowing, speech, or taste.
      Conclusion: STSG reconstructions for pathologic T1-T2 FOM-CA appear to result in acceptable PROM QOL outcomes with the exception of A-FOM tumors having worse chewing outcomes.
      (© 2021 S. Karger AG, Basel.)
    • Contributed Indexing:
      Keywords: Functional outcomes; Oral cavity cancer; Oral cavity reconstruction; Quality of life; Split-thickness skin graft
    • Publication Date:
      Date Created: 20210214 Date Completed: 20210521 Latest Revision: 20210521
    • Publication Date:
      20240628
    • Accession Number:
      10.1159/000512085
    • Accession Number:
      33582667