Neural correlates of memory recovery: Preliminary findings in children and adolescents with acquired brain injury.

Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9005499 Publication Model: Print Cited Medium: Internet ISSN: 1878-3627 (Electronic) Linking ISSN: 09226028 NLM ISO Abbreviation: Restor Neurol Neurosci Subsets: MEDLINE

Publication: Amsterdam : IOS Press
Original Publication: Amsterdam : Elsevier Science Publishers BV, c1989-

Brain Injuries* ; Electroencephalography*; Adolescent ; Brain/diagnostic imaging ; Brain Mapping ; Child ; Humans ; Sleep

Background: After acquired brain injury (ABI), patients show various neurological impairments and outcome is difficult to predict. Identifying biomarkers of recovery could provide prognostic information about a patient's neural potential for recovery and improve our understanding of neural reorganization. In healthy subjects, sleep slow wave activity (SWA, EEG spectral power 1-4.5 Hz) has been linked to neuroplastic processes such as learning and brain maturation. Therefore, we suggest that SWA might be a suitable measure to investigate neural reorganization underlying memory recovery.
Objectives: In the present study, we used SWA to investigate neural correlates of recovery of function in ten paediatric patients with ABI (age range 7-15 years).
Methods: We recorded high-density EEG (128 electrodes) during sleep at the beginning and end of rehabilitation. We used sleep EEG data of 52 typically developing children to calculate age-normalized values for individual patients. In patients, we also assessed every-day life memory impairment at the beginning and end of rehabilitation.
Results: In the course of rehabilitation, memory recovery was paralleled by longitudinal changes in SWA over posterior parietal brain areas. SWA over left prefrontal and occipital brain areas at the beginning of rehabilitation predicted memory recovery.
Conclusions: We show that longitudinal sleep-EEG measurements are feasible in the clinical setting. While posterior parietal and prefrontal brain areas are known to belong to the memory "core network", occipital brain areas have never been related to memory. While we have to remain cautious in interpreting preliminary findings, we suggest that SWA is a promising measure to investigate neural reorganization.

Brain Behav. 2017 Nov 02;7(12):e00832. (PMID: 29299377)
Front Integr Neurosci. 2012 Jun 11;6:31. (PMID: 22701406)
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9. (PMID: 15148381)
J Neurotrauma. 2011 Apr;28(4):503-16. (PMID: 21250917)
Curr Top Behav Neurosci. 2019;41:129-153. (PMID: 30739308)
Annu Rev Neurosci. 2001;24:167-202. (PMID: 11283309)
Neuron. 2015 Oct 7;88(1):33-46. (PMID: 26447571)
Curr Opin Neurobiol. 2004 Apr;14(2):212-7. (PMID: 15082327)
Brain Inj. 2015;29(7-8):951-4. (PMID: 25962923)
Neuroreport. 2000 Oct 20;11(15):3321-5. (PMID: 11059895)
Neuropsychologia. 2015 Aug;75:450-7. (PMID: 26142352)
Neuroimage. 2018 Apr 1;169:302-311. (PMID: 29277405)
Childs Nerv Syst. 2017 Oct;33(10):1683-1692. (PMID: 29149383)
Cereb Cortex. 2014 Nov;24(11):3036-45. (PMID: 23800722)
Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R533-40. (PMID: 22116514)
Sleep. 2015 Apr 01;38(4):607-14. (PMID: 25669190)
J Comp Neurol. 1997 Oct 20;387(2):167-78. (PMID: 9336221)
Int J Psychophysiol. 2007 Jun;64(3):247-58. (PMID: 17126436)
Neuropsychologia. 2011 Jul;49(8):2246-57. (PMID: 21329712)
J Theor Biol. 1990 Jan 23;142(2):149-61. (PMID: 2161971)
Neurorehabil Neural Repair. 2017 Oct-Nov;31(10-11):864-876. (PMID: 29233071)
J Neurotrauma. 2012 Mar 1;29(4):678-705. (PMID: 21644810)
Curr Opin Neurobiol. 2006 Jun;16(3):258-64. (PMID: 16713245)
Dev Psychobiol. 2017 Jan;59(1):5-14. (PMID: 27401676)
Neuropsychologia. 2016 Sep;90:12-24. (PMID: 26827916)
Dev Med Child Neurol. 2008 Mar;50(3):168-81. (PMID: 18190537)
Dev Neuropsychol. 2016 Apr;41(3):176-200. (PMID: 27232263)
Hippocampus. 2015 Aug;25(8):877-83. (PMID: 25639205)
Nat Neurosci. 1999 Oct;2(10):861-3. (PMID: 10491603)
Neuron. 2014 Jan 8;81(1):12-34. (PMID: 24411729)
Handb Clin Neurol. 2013;112:913-20. (PMID: 23622301)
Cereb Cortex. 2011 Mar;21(3):607-15. (PMID: 20624840)
Nat Rev Neurosci. 2012 Oct;13(10):713-26. (PMID: 22992647)
Cortex. 2013 Mar;49(3):646-57. (PMID: 22482692)
Behav Brain Res. 2013 Oct 1;254:8-21. (PMID: 23428745)
Prog Brain Res. 2011;193:63-82. (PMID: 21854956)
Neurorehabil Neural Repair. 2014 Feb;28(2):129-38. (PMID: 23980019)
Neurorehabil Neural Repair. 2017 May;31(5):462-474. (PMID: 28162033)
Curr Opin Neurobiol. 2016 Apr;37:1-6. (PMID: 26687618)
J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):210-6. (PMID: 10896695)
Ageing Res Rev. 2015 Nov;24(Pt B):232-62. (PMID: 26318058)
Neuropsychologia. 2011 Jul;49(8):2178-84. (PMID: 21477605)
Nat Rev Neurosci. 2017 Feb 17;18(3):183-192. (PMID: 28209980)
Neurosci Biobehav Rev. 2015 May;52:21-37. (PMID: 25704073)
Brain. 2007 Oct;130(Pt 10):2508-19. (PMID: 17872928)
Dev Neuropsychol. 2010;35(3):318-32. (PMID: 20446135)
J Neurosci. 2014 Sep 10;34(37):12568-75. (PMID: 25209294)
Sleep. 2004 Jun 15;27(4):774-83. (PMID: 15283014)
Neuroimage. 2010 Jan 1;49(1):905-13. (PMID: 19732835)
Brain. 2008 Dec;131(Pt 12):3209-21. (PMID: 18952679)
J Head Trauma Rehabil. 2015 Nov-Dec;30(6):402-10. (PMID: 24901328)
Neuroimage. 2012 Nov 1;63(2):959-65. (PMID: 22498654)
J Neurosci. 2010 Oct 6;30(40):13211-9. (PMID: 20926647)
J Neuropsychol. 2011 Mar;5(Pt 1):15-38. (PMID: 21366885)
Dev Med Child Neurol. 2003 Dec;45(12):821-8. (PMID: 14667074)
Neuroimage Clin. 2019;23:101844. (PMID: 31075554)
Lancet Neurol. 2008 May;7(5):425-35. (PMID: 18420156)
J Exp Child Psychol. 2014 Nov;127:144-62. (PMID: 24630759)
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5177-80. (PMID: 19307577)
J Neurosci. 2008 Apr 2;28(14):3586-94. (PMID: 18385317)
Brain. 2009 Jul;132(Pt 7):1882-8. (PMID: 19482967)
Cereb Cortex. 2019 Feb 1;29(2):657-665. (PMID: 29329367)
Dev Cogn Neurosci. 2012 Oct;2(4):381-95. (PMID: 22770728)
Hum Brain Mapp. 2015 Jul;36(7):2432-42. (PMID: 25757914)
Neuroimage Clin. 2019;22:101773. (PMID: 30991615)
Curr Biol. 2017 Feb 6;27(3):465-470. (PMID: 28111154)
Nature. 2004 Jul 1;430(6995):78-81. (PMID: 15184907)

Keywords: EEG; biomarkers; longitudinal changes; neural reorganization; sleep

Date Created: 20210213 Date Completed: 20211214 Latest Revision: 20211214

20221213

PMC7990412

10.3233/RNN-201140

33579882