A critical review and meta-analysis of epidemiology studies of occupationally exposed styrene workers evaluated for chromosomal aberration incidence.

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  • Author(s): Collins JJ;Collins JJ; Moore M; Moore M
  • Source:
    Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2021 Jan-Feb; Vol. 861-862, pp. 503275. Date of Electronic Publication: 2020 Oct 22.
  • Publication Type:
    Journal Article; Meta-Analysis; Systematic Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101632149 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3592 (Electronic) Linking ISSN: 13835718 NLM ISO Abbreviation: Mutat Res Genet Toxicol Environ Mutagen Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier, 1997-
    • Subject Terms:
      Chromosome Aberrations*; Occupational Diseases/*epidemiology ; Occupational Exposure/*adverse effects ; Styrene/*adverse effects; Humans ; Incidence ; Occupational Diseases/chemically induced ; United States/epidemiology
    • Abstract:
      Chromosome aberrations in the peripheral blood lymphocytes of styrene exposed workers have been suggested as a potential early marker for cancer risk. We performed a critical review and abstracted data from all studies using current chromosome aberration scoring criteria and providing at least a mean and standard deviation or standard error for the exposed and comparison groups. Using these data, we conducted a meta-analysis of occupational styrene exposed workers and incidence of chromosome aberrations. Our meta-analysis used the standardized mean difference as the summary statistic since all studies assess the same outcome but use different comparison populations. The primary meta-analysis of the 20 comparisons of 505 styrene exposed workers to 532 comparison workers found a meta-mean difference of 0.361 (95 % CI -0.084 to 0.807, random effects model), but there was substantial lack of consistency across studies (I2 of 90.11, p-value <0.001, fixed effect model). Studies with higher styrene exposures had lower mean standard differences compared to studies with lower styrene exposures. While studies of styrene workers overall had a slight increase in chromosomal aberrations relative to comparison groups, the lack of consistency across studies and the absence of an exposure response and other limitations of the reviewed studies including inadequate exposure assessment, small numbers of participants per study, and poorly matched exposed and comparison workers, we find insufficient evidence to support a conclusion that styrene exposure increases chromosome aberration frequencies in styrene workers.
      (Copyright © 2020 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Bio-monitoring; Cancer risk; Chromosome aberrations; Meta-analysis; Occupational study; Styrene
    • Accession Number:
      44LJ2U959V (Styrene)
    • Publication Date:
      Date Created: 20210208 Date Completed: 20210315 Latest Revision: 20210920
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.mrgentox.2020.503275
    • Accession Number:
      33551094