Associations of Vascular Risk with Cognition, Brain Glucose Metabolism, and Clinical Progression in Cognitively Intact Elders.

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  • Additional Information
    • Corporate Authors:
      Alzheimer’s Disease Neuroimaging Initiative
    • Source:
      Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam ; Washington : IOS Press, c1998-
    • Subject Terms:
      Brain Chemistry*; Cognitive Dysfunction/*complications ; Dementia/*complications ; Glucose/*metabolism ; Vascular Diseases/*complications; Aged ; Amyloid beta-Protein Precursor/metabolism ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/psychology ; Cross-Sectional Studies ; Databases, Factual ; Dementia/diagnostic imaging ; Dementia/psychology ; Disease Progression ; Executive Function ; Female ; Humans ; Kaplan-Meier Estimate ; Longitudinal Studies ; Male ; Mental Status and Dementia Tests ; Middle Aged ; Neuroimaging ; Positron-Emission Tomography ; Risk Factors ; Vascular Diseases/diagnostic imaging
    • Abstract:
      Background: Increasing evidence supports an important role of vascular risk in cognitive decline and dementia.
      Objective: This study aimed to examine whether vascular risk was associated with cognitive decline, cerebral hypometabolism, and clinical progression in cognitively intact elders.
      Methods: Vascular risk was assessed by the Framingham Heart Study general Cardiovascular disease (FHS-CVD) risk score. The cross-sectional and longitudinal associations of FHS-CVD risk score with cognition and brain glucose metabolism were explored using multivariate linear regression and linear mixed effects models, respectively. The risk of clinical progression conversion was assessed using Kaplan-Meier survival curves and multivariate Cox proportional hazard models.
      Results: A total of 491 cognitively intact elders were included from Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Participants with high FHS-CVD risk scores had lower baseline Mini-Mental State Examination (MMSE) (p = 0.009), executive function (EF) (p < 0.001), memory function (MEM) (p < 0.001) scores, and F18-fluorodeoxyglucose positron emission tomography (FDG-PET) uptake (p < 0.001) than those with low FHS-CVD risk scores. In longitudinal analyses, individuals with higher FHS-CVD risk scores had greater longitudinal declines in MMSE (p = 0.043), EF (p = 0.029) scores, and FDG-PET uptake (p = 0.035). Besides, individuals with a higher vascular risk had an increased risk of clinical progression (p = 0.004).
      Conclusion: These findings indicated effects of vascular risk on cognitive decline, cerebral hypometabolism, and clinical progression. Early detection and management of vascular risk factors might be useful in the prevention of dementia.
    • Contributed Indexing:
      Keywords: Clinical progression; FDG-PET; cognition; dementia; vascular risk
    • Accession Number:
      0 (APP protein, human)
      0 (Amyloid beta-Protein Precursor)
      IY9XDZ35W2 (Glucose)
    • Publication Date:
      Date Created: 20210201 Date Completed: 20210913 Latest Revision: 20210913
    • Publication Date:
      20240829
    • Accession Number:
      10.3233/JAD-201117
    • Accession Number:
      33523005