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The life and works of Dr Brian Bernard Newbould (28nd Jan 1934-25th Nov, 2016) B. Pharm, FR PharmS, PhD.
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- Author(s): Rainsford KD;Rainsford KD
- Source:
Inflammopharmacology [Inflammopharmacology] 2021 Apr; Vol. 29 (2), pp. 339-342. Date of Electronic Publication: 2021 Jan 27.- Publication Type:
Biography; Editorial; Historical Article; Portrait- Language:
English - Source:
- Additional Information
- Source: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE
- Publication Information: Publication: Basel ; Boston : Birkhäuser
Original Publication: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991- - Subject Terms:
- Subject Terms: Newbould B
- References: Billingham MEJ, Rushton AR (1985) Clozic. In: Rainsford KD (ed) Antirheumatic drugs, experimental agents and clinical aspects of drug use. Boca Raton CRC Press, Fl.
Chalmers TM, Kellgren JH, Platt DS (1969) Evaluation in man of fenclozic acid (ICI 54,450, Myelex), a new anti-inflammatory agent. Clin Ann Rheum Dis 28:295.
Dudley Hart F, Bain LS, Huskisson EC, Littler TR, Taylor RT (1970) Hepatic effects of fenclozic acid. Ann Rheum Dis 29:684. (PMID: 10.1136/ard.29.6.684)
Franklin TJ, Newbould BB, O’Mant DM, Scott AI, Stacey GJ, Davies GE (1966) A new type of cytotoxic immunosuppressive agent: 3-acetyl-5-(4-fluorobenzylidene)-4-hydroxy-2-oxo-2:5-dihyrothiopen. Nature 210:638–639. (PMID: 10.1038/210638a0)
Hepworth W, Newbould BB, Platt DS, Stacey GJ (1968) Studies with certain anti-inflammatory and immune-suppressive agents on adjuvant-induced arthritis in rats and other experimental models. Proc Joint Meeting between the Italian and Br Pharmacol Soc.
Hepworth W, Newbould BB, Platt DS, Stacey GJ (1968) 2-(4-chlorophenyl) thiazol-4-yl acetic acid (‘MYALEX’) A new compound with anti-inflammatory, analgesic and anti-pyretic activity. Nat London 221:582–583. (PMID: 10.1038/221582b0)
Koga T, Sande BV, Yeaton R, Pearson CM (1976) Re-evaluation of inguinal lymph node injection for the production of adjuvant arthritis in the rats. Int Arch Allergy Appl Immunol 51:359–367. (PMID: 10.1159/000231609)
Morgan GJ, Peter JB, Newbould BB (1969) Experimental polymyositis. Arth Rheumat 12:317 (Abstract).
Morgan GJ, Peter JB, Newbould BB (1971) Experimental allergic myositis in rats. Arthr Rheum 14:599. (PMID: 10.1002/art.1780140507)
Newbould BB (1963) Chemotherapy of arthritis induced in rates by mycobacterial adjuvant. Br J Pharmacol Chem 21:127–136 (621 Citation).
Newbould BB (1963a) Adjuvant-induced arthritis in rats. Proc 1963 Meeting of the British Pharmacological society.
Newbould BB (1964) Lymphatic drainage and adjuvant-induced arthritis in rats. Br J Exp Pathol 45:375–383. (PMID: 142031922094326)
Newbould BB (1964a) The role of lymph nodes in the development of adjuvant-induced arthritis in rats. Proc British Society for Immunology.
Newbould BB (1964c) Role of lymph nodes in adjuvant-induced arthritis in rats. Ann Rheumat Dis.
Newbould BB (1964d) Chemotherapeutic suppression of adjuvant-induced arthritis in rats. Br Soc Immunol.
Newbould BB (1965a) Production of experimental allergic encephalomyelitis in rats by injections of spinal cord adjuvant into the inguinal lymph nodes. Immunology 9:613–614. (PMID: 1423608)
Newbould BB (1965b) Chemotherapeutic studies on adjuvant-induced arthritis and allergic encephalomyeltis. Br Pharmacol Soc 12:9–34.
Newbould BB (1965c) Suppression of adjuvant-induced arthritis in rats with 2-butoxy carbonyl methylene-4-oxo thiazolidine. Br J Pharmacol Chemother 24:632–640. (PMID: 10.1111/j.1476-5381.1965.tb01619.x)
Newbould BB (1966a) Production of allergic encephalomyelitis and other syndromes involving an immune response by intra-lymph node injection of antigen/adjuvant emulsions. Br Soc Immunol.
Newbould BB (1966b) Studies with 3-acetyl-5-(4-fluorobenzylidene)-4-hydroxy-2-oxo-2:5-dihyrothiopen (ICI 47,776) on adjuvant induced arthritis allergic encephalomyelitis and allergic thyroiditis in rats. Br Soc Immunol.
Newbould BB (1967) The evaluation and potential utility of compounds which modify the development of adjuvant disease in rats. Invited Am Chem Soc Symp Anti Inflam Comp.
Newbould BB (1968a) Attempted inhibition of adjuvant-induced arthritis allergic encephalomyelitis and allergic thyroiditis in rats with certain antisera and chemotherapeutic agents. Proc Meeting of the British Society for Immunology.
Newbould BB (1968b) Studies on adjuvant-induced arthritis in rats. Proc International Symposium of Inflammation Biochemistry and Drug Interaction – Como – October 1968.
Newbould BB (1969a) Selective suppression with rabbit anti-rat thymocyte serum and rabbit anti-tuberculous serum of adjuvant-induced arthritis (AIA); Expt allergic encephalomyelitis (EAE) and Expt allergic thyroiditis in rats. Arth Rheum 12:31.
Newbould BB (1969b) The Phamacology of 2-(4-chlorophenyl) thiazol-4-yl acetic acid (ICI 54,540; ‘MYALEX’); a new compound with anti-inflammatory, analgesic and anti-pyretic activity. Br J Phamacol 35:487–489. (PMID: 10.1111/j.1476-5381.1969.tb08290.x)
Newbould BB (1980) Risk benefit analysis in drug research: the effect on industry. Proc Society for Drug Res Canterbury.
Newbould BB (1981) Implications for management of new directions in pharmaceutical research. Proc Pharma 81:12.
Newbould B B (1981) How does marketing research serve the needs of new product research and development. Proc Market Research Meeting Industrial Pharmacists Group London.
Newbould BB (1981) Does regulatory control influence the search for new drugs? Proc Br Instit Regu Affairs Symp Guildford.
Newbould BB (1986) Life Sciences Phamaceuticals. Proc Anglo-Japn High Technol Industrial Forum.
Newbould BB (1986) The future of drug discovery. Proc Society For Drug Research – London.
Newbould B (1986) The Innovation Process – A British Example. Proc Anglo-Japanese High Technology Industrial Forum.
Newbould BB (1989) Research results and business success. Proc Management Centre Europe – Zurich –.
Newbould BB (1989) ICI Pharmaceuticals. Proc Asian Medical News 10th Anniversary Edition – March 1989.
Newbould, B B. (1989) Future Trends in World-wide Pharmaceutical R&D. Proc Future Trends in Pharmaceutical Research Seminar – Bangkok – Thailand – April 1989.
Newbould BB (1990) How are medicines discovered? Chapter book – Pharmaceutical Medicine.
Newbould BB (1992) The birth and growth of the pharmaceutical industry. Proc Duncan Davies Memorial Medal Lecture at the Research and Development Society.
Newbould BB (1993) Eastern European R&D Resources – A Challenge for EIMRA Members. Contribution on Experience to Round Table Meeting – France.
Newbould, B B. (1993) The industrialist’s perception of post-16 education and training. Proc Ann Assoc Sci.
Newbould BB, Kilpatrick R (1959) Some information on long acting sulphonamides. Proc 1959 Meeting of the British Pharmacological Society.
Newbould BB, Kilpatrick R (1959) The inhibitory effect of plasma proteins on the antibacterial activity of some new sulphonamides. Proc 1959 of the British Phamacological Society.
Newbould BB, Kilpatrick R (1960) Long-acting sulphonamides and protein-binding. Lancet 1960(1):887–891. (PMID: 10.1016/S0140-6736(60)90784-4)
Newbould BB, Philipps NJ (1992) (1992) An industrial perspective – The ICI View. Biologist 39:5.
Newbould BB, Pearson CM, Whitehouse MW (2019) Passive transfer of allergic encephalomyelitis in rats—a tool for detecting late-acting immunosuppressants. Inflammopharmacology. https://doi.org/10.1007/s10787-019-00565-w (in press).
Pearson CM (1956) Development of arthritis, periarthritis and periostosis in rats given adjuvants. Proc Soc exp Biol 91:95–101. (PMID: 10.3181/00379727-91-22179)
Pearson CM (1959) Development of arthritis in the rat following injection with adjuvant. In: Shaffer JH, Lo Grippo GA, Chase MW (eds) Mechanisms of hypersensitivity. Little Brown, Boston.
Pearson CM, Newbould BB, Whitehouse DJ, Whitehouse M (1969) Conditions required for the cell mediated transfer of adjuvant-induced arthritis, allergic encephalomyelitis and allergic thyroiditis. Arth Rheum 12:322.
Pearson CM (1976) Lymphocyte depletion in patients with rheumatoid arthritis. Agents Actions 6:28–31. (PMID: 10.1007/BF01972182)
Pearson CM, Wood FD (1959) Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant. General clinical and pathological characteristics and some modifying factors. Arth Rheum 2:440–459. (PMID: 10.1002/1529-0131(195910)2:5<440::AID-ART1780020510>3.0.CO;2-N)
Pearson CM, Wood FD (1963) Studies of arthritis and other lesions in rats by the injection of mycobacterial adjuvant VII. Pathologic details of the arthritis and spondylitis. Am J Path 42:73–95. (PMID: 13942247)
Rodrigues AVM, Rollison HE, Martin S, Sarda S, Schulz-Utermochl SSS, Gustafsson F, Eakins J, Kenna JG, Wilson ID (2013) In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid. Arch Toxicol 87:1569–1579. (PMID: 10.1007/s00204-013-1056-y)
Sokoloff MC, Newbould BB (1970) Suppression of experimental allergic encephalomyelitis (EAE) by methotrexate (MTX) with Folinic Acid (FA) rescue. Arthritis Rheum 13:350. (PMID: 10.1002/art.1780130203)
Stoerk HC, Bielinski TC, Budzilovich T (1954) Chronic polyarthritis in rats injected with spleen in adjuvants. Am J Path 30:616.
Whitehouse DJ, Whitehouse MW, Pearson CM (1969) Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes. Nature 224:1322. (PMID: 10.1038/2241322a0)
Whitehouse MW (2007) Adjuvant arthritis 50 years on: the impact of the 1956 article by CM Pearson: Development of arthritis, periarthritis and periostitis in rats given adjuvants. Inflamm Res 56:133–138. (PMID: 10.1007/s00011-006-6117-8) - Publication Date: Date Created: 20210127 Date Completed: 20211124 Latest Revision: 20211124
- Publication Date: 20231215
- Accession Number: 10.1007/s10787-020-00778-4
- Accession Number: 33502704
- Source:
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