Human bocavirus genotypes 1, 2, and 3 circulating in pediatric patients with acute gastroenteritis in Chiang Mai, Thailand, 2012-2018.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: England NLM ID: 101487384 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-035X (Electronic) Linking ISSN: 18760341 NLM ISO Abbreviation: J Infect Public Health Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Elsevier, 2008-
    • Subject Terms:
      Gastroenteritis/*virology ; Human bocavirus/*genetics ; Parvoviridae Infections/*diagnosis; Child ; Child, Preschool ; Feces/virology ; Female ; Gastroenteritis/diagnosis ; Gastroenteritis/epidemiology ; Genome, Viral ; Genotype ; Human bocavirus/isolation & purification ; Humans ; Infant ; Male ; Parvoviridae Infections/epidemiology ; Parvoviridae Infections/virology ; Phylogeny ; Thailand/epidemiology
    • Abstract:
      Background: Global distribution of human bocavirus (HBoV) has been known to associate with viral gastroenteritis in pediatric population. This study was conducted in Chiang Mai, Thailand from 2012 to 2018 to investigate epidemiology and genotype distribution of HBoV in pediatric patients less than 5 years old hospitalized with diarrhea.
      Methods: A total of 2727 fecal specimens were investigated for the presence of HBoV using nested-PCR targeting partial VP1 capsid region. The detected HBoV strains were further characterized by nucleotide sequencing and phylogenetic analysis.
      Results: Detection rate of HBoV infection in pediatric patients with acute diarrhea was 5.2%. Three genotypes of HBoV were detected with the most predominance of HBoV1 (50.4%), followed by HBoV2 (42.5%), and HBoV3 (7.1%). The majority of HBoV positive cases were children of 1 to <2 years old (31.9%) with high detection rate of HBoV1 and HBoV2. HBoV infection occurred all year-round. Phylogenetic analysis revealed that majority of HBoV1 displayed the genetic relationship with HBoV1 strains reported previously from Asia whereas only a few were related to the strains from Europe, South America, and Middle East. The HBoV2 and HBoV3 were also mainly closely related to the strains reported from Asia and a few from South America and North Africa.
      Conclusions: This study highlights distribution of HBoV genotypes circulating in pediatric patients with acute gastroenteritis in Chiang Mai, Thailand. Overall, three genotypes of HBoV were detected with equally high prevalence of HBoV1 and HBoV2 whereas HBoV3 was detected with much lower prevalence.
      (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
    • Contributed Indexing:
      Keywords: Acute gastroenteritis; Bocavirus; Genotypes; Pediatric; Surveillance; Thailand
    • Publication Date:
      Date Created: 20210124 Date Completed: 20210305 Latest Revision: 20210305
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.jiph.2020.12.007
    • Accession Number:
      33486373