[Clinicopathological features of children with lupus nephritis with positive antineutrophil cytoplasmic antibody].

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  • Additional Information
    • Source:
      Publisher: Zhongguo dang dai er ke za zhi she Country of Publication: China NLM ID: 100909956 Publication Model: Print Cited Medium: Print ISSN: 1008-8830 (Print) Linking ISSN: 10088830 NLM ISO Abbreviation: Zhongguo Dang Dai Er Ke Za Zhi Subsets: MEDLINE
    • Publication Information:
      Original Publication: Changsha : Zhongguo dang dai er ke za zhi she, 1999-
    • Subject Terms:
      Antibodies, Antineutrophil Cytoplasmic* ; Lupus Nephritis*; Child ; Creatinine ; Humans ; Kidney ; Retrospective Studies
    • Abstract:
      Objective: To study the clinicopathological features of children with lupus nephritis (LN) with positive anti-neutrophil cytoplasmic antibody (ANCA).
      Methods: A retrospective analysis was performed for the children who were diagnosed with LN in the First Affiliated Hospital of Sun Yat-sen University from January 2003 to December 2019. According to the results of serum ANCA, they were divided into two groups: ANCA-positive group ( n =59) and ANCAnegative group ( n =454). The two groups were compared in terms of clinical manifestations, histopathological features, remission rate, and prognosis.
      Results: Compared with the ANCA-negative group, the ANCA-positive group had a significant reduction in leukocytes and a significant increase in erythrocyte sedimentation rate ( P < 0.05). There were no significant differences between the two groups in serum creatinine, urine protein, and urine red blood cell count ( P > 0.05). A total of 308 children underwent kidney biopsy. The results on light microscopy showed that compared with the ANCAnegative group, the ANCA-positive group had a significantly higher proportion of children with cellular fibrous crescents ( P < 0.05) and a significantly lower proportion of children with immune complex deposition ( P < 0.05). There were no significant differences between the two groups in the remission rate and survival rate ( P > 0.05).
      Conclusions: Children with ANCA-positive LN tend to have more severe renal pathological injury, which is not exactly parallel with clinical manifestations, suggesting that timely renal biopsy is of great importance.
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    • Accession Number:
      0 (Antibodies, Antineutrophil Cytoplasmic)
      AYI8EX34EU (Creatinine)
    • Publication Date:
      Date Created: 20210121 Date Completed: 20210127 Latest Revision: 20240805
    • Publication Date:
      20240805
    • Accession Number:
      PMC7818163
    • Accession Number:
      33476538