Synchrotron radiation X-ray microtomography for the visualization of intra-cochlear anatomy in human temporal bones implanted with a perimodiolar cochlear implant electrode array.

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  • Additional Information
    • Source:
      Publisher: Wiley Online Library Country of Publication: United States NLM ID: 9888878 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-5775 (Electronic) Linking ISSN: 09090495 NLM ISO Abbreviation: J Synchrotron Radiat Subsets: MEDLINE
    • Publication Information:
      Publication: [Malden, MA] : Wiley Online Library
      Original Publication: Copenhagen : Wiley-Blackwell Munksgaard, c1994-
    • Subject Terms:
      Cochlear Implants*; Cochlea/*anatomy & histology ; Temporal Bone/*diagnostic imaging ; X-Ray Microtomography/*methods; Electrodes, Implanted ; Humans ; Imaging, Three-Dimensional ; In Vitro Techniques ; Radiographic Image Interpretation, Computer-Assisted ; Synchrotrons
    • Abstract:
      Recently, synchrotron radiation computed microtomography (SRµCT) has emerged as a promising tool for non-destructive, in situ visualization of cochlear implant electrode arrays inserted into a human cochlea. Histological techniques have been the `gold standard' technique for accurate localization of cochlear implant electrodes but are suboptimal for precise three-dimensional measurements. Here, an SRµCT experimental setup is proposed that offers the benefit of a high spatial and contrast resolution (isotropic voxel size = 4.95 µm and propagation-based phase-contrast imaging), while visualizing the soft-tissue structures and electrode array of the cochlear implant simultaneously. In this work, perimodiolar electrode arrays have been tested, which incorporate thick and closely spaced platinum-iridium contacts and wiring. These data can assist cochlear implant and hearing research, can be used to verify electrode segmentation techniques for clinical computed tomography or could be utilized to evaluate cochlear implant electrode array designs.
    • Grant Information:
      12R5118N Fonds Wetenschappelijk Onderzoek; UABR/11/004 Hercules Foundation
    • Contributed Indexing:
      Keywords: cochlear implants; perimodiolar electrodes; phase-contrast imaging; synchrotron X-ray microtomography
    • Publication Date:
      Date Created: 20210105 Date Completed: 20210906 Latest Revision: 20210906
    • Publication Date:
      20240829
    • Accession Number:
      10.1107/S1600577520014952
    • Accession Number:
      33399585