Atypical Enteropathogenic Escherichia coli: from Kittens to Humans and Beyond!

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  • Author(s): Bhatt S;Bhatt S
  • Source:
    Infection and immunity [Infect Immun] 2021 Feb 16; Vol. 89 (3). Date of Electronic Publication: 2021 Feb 16 (Print Publication: 2021).
  • Publication Type:
    Journal Article; Comment
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : American Society For Microbiology
      Original Publication: [Bethesda, Md.] American Society for Microbiology.
    • Subject Terms:
      Enteropathogenic Escherichia coli*/genetics ; Escherichia coli Infections*/veterinary; Animals ; Base Sequence ; Cats ; Diarrhea ; Female ; Humans ; Virulence
    • Abstract:
      Atypical enteropathogenic Escherichia coli (aEPEC) are associated with diarrhea worldwide, yet genome-wide investigations to probe their virulome are lacking. In this issue of Infection and Immunity , V. E. Watson, T. H. Hazen, D. A. Rasko, M. E. Jacob, et al. (IAI 89:e00619-20, 2020, https://doi.org/10.1128/IAI.00619-20) sequenced aEPEC isolates from diarrheic and asymptomatic kittens. Using phylogenomics, they demonstrated that these isolates were genetically indistinguishable from human isolates, suggesting that kittens may serve as a reservoir and, perhaps, a much-needed model to interrogate aEPEC virulence. The diarrheic isolates were hypermotile, suggesting that this phenotype may distinguish virulent strains from their innocuous counterparts.
      (Copyright © 2021 American Society for Microbiology.)
    • Comments:
      Comment on: Infect Immun. 2021 Feb 16;89(3):. (PMID: 33257534)
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    • Contributed Indexing:
      Keywords: EAF plasmid; atypical EPEC; human; kitten; typical EPEC; virulence
    • Publication Date:
      Date Created: 20201228 Date Completed: 20210712 Latest Revision: 20210817
    • Publication Date:
      20221213
    • Accession Number:
      PMC8097266
    • Accession Number:
      10.1128/IAI.00752-20
    • Accession Number:
      33361199