A Primer on Dose-Response Data Modeling in Radiation Therapy.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE
    • Publication Information:
      Publication: New York, NY : Elsevier, Inc
      Original Publication: Elmsford, N. Y., Pergamon Press.
    • Subject Terms:
      Data Analysis* ; Dose-Response Relationship, Radiation* ; Radiation Dose Hypofractionation*; Radiation Pneumonitis/*etiology ; Radiotherapy/*statistics & numerical data; Confidence Intervals ; Goals ; Humans ; Likelihood Functions ; Logistic Models ; Lung/radiation effects ; Organs at Risk/radiation effects ; Radiation Pneumonitis/pathology ; Radiotherapy/adverse effects ; Uncertainty
    • Abstract:
      An overview of common approaches used to assess a dose response for radiation therapy-associated endpoints is presented, using lung toxicity data sets analyzed as a part of the High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic effort as an example. Each component presented (eg, data-driven analysis, dose-response analysis, and calculating uncertainties on model prediction) is addressed using established approaches. Specifically, the maximum likelihood method was used to calculate best parameter values of the commonly used logistic model, the profile-likelihood to calculate confidence intervals on model parameters, and the likelihood ratio to determine whether the observed data fit is statistically significant. The bootstrap method was used to calculate confidence intervals for model predictions. Correlated behavior of model parameters and implication for interpreting dose response are discussed.
      (Copyright © 2020 Elsevier Inc. All rights reserved.)
    • Comments:
      Comment in: Int J Radiat Oncol Biol Phys. 2021 Jun 1;110(2):609. (PMID: 33989579)
      Comment in: Int J Radiat Oncol Biol Phys. 2021 Aug 1;110(5):1541-1543. (PMID: 34024669)
    • References:
      Med Phys. 2018 Oct;45(10):4754-4762. (PMID: 30102783)
      Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):68-86. (PMID: 32921513)
      Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):87-99. (PMID: 29534899)
      Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):754-61. (PMID: 16965865)
      Biom J. 2008 Jun;50(3):419-30. (PMID: 18435502)
      Int J Radiat Oncol Biol Phys. 1998 Aug 1;42(1):1-9. (PMID: 9747813)
      Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):196-205. (PMID: 29482870)
      Int J Radiat Biol. 1997 May;71(5):531-42. (PMID: 9191898)
      Int J Radiat Biol. 1992 Aug;62(2):249-62. (PMID: 1355519)
      Radiother Oncol. 1991 Mar;20(3):166-76. (PMID: 1852908)
      Med Phys. 2012 Mar;39(3):1386-409. (PMID: 22380372)
      Int J Radiat Oncol Biol Phys. 1989 Aug;17(2):433-6. (PMID: 2753766)
      Radiat Oncol. 2007 Jun 07;2:21. (PMID: 17553175)
      Radiother Oncol. 2005 Nov;77(2):176-81. (PMID: 16256230)
      Phys Med Biol. 1999 Apr;44(4):N55-62. (PMID: 10232818)
      Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):457-62. (PMID: 21035956)
      Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):373-81. (PMID: 10661344)
      Int J Radiat Oncol Biol Phys. 2008 Oct 1;72(2):568-74. (PMID: 18793959)
      Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):137-146. (PMID: 29477291)
      Radiat Res Suppl. 1985;8:S13-9. (PMID: 3867079)
      Br J Radiol. 2017 May;90(1073):20160508. (PMID: 28195507)
      Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):335-343. (PMID: 29353652)
      Med Phys. 1983 Jul-Aug;10(4):410-5. (PMID: 6888354)
      Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1236-1243. (PMID: 30353872)
      Int J Radiat Oncol Biol Phys. 1995 Feb 15;31(4):883-91. (PMID: 7860402)
      Radiother Oncol. 1993 Oct;29(1):69-74. (PMID: 8295990)
      Radiat Oncol. 2011 Jun 06;6:61. (PMID: 21645390)
      Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):124-136. (PMID: 31606528)
      J Clin Epidemiol. 1996 Dec;49(12):1373-9. (PMID: 8970487)
      Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):172-187. (PMID: 30496880)
      Med Phys. 2018 Jul;45(7):3449-3459. (PMID: 29763967)
    • Grant Information:
      P30 CA008748 United States CA NCI NIH HHS; R01 CA233487 United States CA NCI NIH HHS; R01 CA238783 United States CA NCI NIH HHS
    • Publication Date:
      Date Created: 20201228 Date Completed: 20210804 Latest Revision: 20220802
    • Publication Date:
      20231215
    • Accession Number:
      PMC9339232
    • Accession Number:
      10.1016/j.ijrobp.2020.11.020
    • Accession Number:
      33358230