Mitochondrial RNA quality control in trypanosomes.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Author(s): Aphasizheva I;Aphasizheva I; Aphasizhev R; Aphasizhev R; Aphasizhev R
  • Source:
    Wiley interdisciplinary reviews. RNA [Wiley Interdiscip Rev RNA] 2021 May; Vol. 12 (3), pp. e1638. Date of Electronic Publication: 2020 Dec 16.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: United States NLM ID: 101536955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-7012 (Electronic) Linking ISSN: 17577004 NLM ISO Abbreviation: Wiley Interdiscip Rev RNA Subsets: MEDLINE
    • Publication Information:
      Original Publication: Hoboken, NJ : Wiley, 2010-
    • Subject Terms:
    • Abstract:
      Unicellular parasites Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a spectrum of diseases that jeopardize public health and afflict the economy in sub-Saharan Africa. These hemoflagellates are distinguished by a single mitochondrion, which contains a kinetoplast nucleoid composed of DNA and histone-like proteins. Kinetoplast DNA (kDNA) represents a densely packed network of interlinked relaxed circular molecules: a few ~23-kb maxicircles encoding ribosomal RNAs (rRNAs) and proteins, and approximately 5,000 1-kb minicircles bearing guide RNA (gRNA) genes. The transcription start site defines the mRNA's 5' terminus while the primary RNA is remodeled into a monocistronic messenger by 3'-5' exonucleolytic trimming, 5' and 3' end modifications, and, in most cases, by internal U-insertion/deletion editing. Ribosomal and guide RNA precursors are also trimmed, and the processed molecules are uridylated. For 35 years, mRNA editing has attracted a major effort, but more recently the essential pre- and postediting processing and turnover events have been discovered and the key effectors have been identified. Among these, pentatricopeptide repeat (PPR) RNA binding proteins emerged as conduits coupling modifications of mRNA termini with internal sequence changes introduced by editing. Among 39 annotated PPRs, 20 belong to ribosomal subunits or assembly intermediates, four function as polyadenylation factors, a single factor directs 5' mRNA modification, and one protein is found in F1-ATPase. Nuclear and mitochondrial RNases P consist of a single PPR polypeptide, PRORP1 and PROP2, respectively. Here, we review PPR-mediated mitochondrial processes and discuss their potential roles in mRNA maturation, quality control, translational activation, and decay. This article is categorized under: RNA Processing > Capping and 5' End Modifications RNA Processing > 3' End Processing RNA Processing > RNA Editing and Modification.
      (© 2020 Wiley Periodicals LLC.)
    • References:
      Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1067-71. (PMID: 12552132)
      Wiley Interdiscip Rev RNA. 2013 Mar-Apr;4(2):167-79. (PMID: 23424172)
      Nat Commun. 2019 Jan 11;10(1):146. (PMID: 30635574)
      Nucleic Acids Res. 2020 Sep 25;48(17):9747-9761. (PMID: 32853372)
      J Biol Chem. 2003 Aug 29;278(35):32753-62. (PMID: 12801929)
      RNA. 2002 Jan;8(1):57-68. (PMID: 11871660)
      Nat Rev Mol Cell Biol. 2020 Sep;21(9):542-556. (PMID: 32483315)
      Nucleic Acids Res. 1999 Mar 1;27(5):1377-85. (PMID: 9973629)
      Mol Cell. 2011 Apr 8;42(1):106-17. (PMID: 21474072)
      J Biol Chem. 2013 Nov 15;288(46):32963-78. (PMID: 24089529)
      Nature. 1981 Apr 9;290(5806):470-4. (PMID: 7219536)
      Mol Biochem Parasitol. 1992 Jun;52(2):231-40. (PMID: 1352374)
      Mol Cell Biol. 2000 Apr;20(7):2308-16. (PMID: 10713154)
      Trends Biochem Sci. 2000 Feb;25(2):46-7. (PMID: 10664580)
      Nucleic Acids Res. 2019 Apr 23;47(7):3640-3657. (PMID: 30698753)
      J Biol Chem. 2000 Dec 1;275(48):37907-14. (PMID: 10993905)
      Nat Commun. 2016 Apr 18;7:11285. (PMID: 27088764)
      Nucleic Acids Res. 1989 Jul 25;17(14):5427-45. (PMID: 2762144)
      Nucleic Acids Res. 2019 Apr 23;47(7):3728-3738. (PMID: 30753696)
      Mol Biochem Parasitol. 2007 Apr;152(2):203-12. (PMID: 17292489)
      Mol Cell Biol. 2005 Mar;25(5):1634-44. (PMID: 15713623)
      RNA. 2005 May;11(5):763-73. (PMID: 15811918)
      Wiley Interdiscip Rev RNA. 2018 Sep;9(5):e1487. (PMID: 29888550)
      Cell. 2002 Mar 8;108(5):637-48. (PMID: 11893335)
      Mol Cell Biol. 1991 Dec;11(12):5878-84. (PMID: 1719373)
      Mol Cell. 2016 Feb 4;61(3):364-378. (PMID: 26833087)
      Mol Cell. 2018 Dec 6;72(5):805-812. (PMID: 30526871)
      Plant J. 2016 Feb;85(4):532-47. (PMID: 26764122)
      Trends Parasitol. 2020 Apr;36(4):337-355. (PMID: 32191849)
      Nucleic Acids Res. 2020 Sep 4;48(15):8645-8662. (PMID: 32614436)
      Gene. 2001 Jul 11;272(1-2):209-18. (PMID: 11470527)
      Curr Opin Struct Biol. 2019 Feb;54:43-49. (PMID: 30708253)
      Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):765-7. (PMID: 12552110)
      PLoS Genet. 2012;8(8):e1002910. (PMID: 22916040)
      Cell. 1990 Jul 27;62(2):391-7. (PMID: 1695552)
      Cell. 1990 Jun 1;61(5):885-94. (PMID: 2140530)
      PLoS One. 2013;8(3):e57286. (PMID: 23472078)
      J Biol Chem. 1992 Jan 15;267(2):1123-8. (PMID: 1730639)
      Biochim Biophys Acta. 2013 Feb;1833(2):286-94. (PMID: 22450032)
      Trends Plant Sci. 2009 Sep;14(9):497-504. (PMID: 19716749)
      Plant Cell. 2004 Aug;16(8):2089-103. (PMID: 15269332)
      Science. 2020 Aug 7;369(6504):656-663. (PMID: 32586950)
      Science. 2019 Sep 13;365(6458):1144-1149. (PMID: 31515389)
      Trends Plant Sci. 2008 Dec;13(12):663-70. (PMID: 19004664)
      RNA. 2020 Jan;26(1):69-82. (PMID: 31704716)
      Science. 2018 Oct 26;362(6413):. (PMID: 30213880)
      Mol Cell. 2008 Oct 24;32(2):198-209. (PMID: 18951088)
      Mol Cell Biol. 2010 Mar;30(6):1555-67. (PMID: 20086102)
      Mol Microbiol. 2016 Mar;99(6):1043-58. (PMID: 26713541)
      Biochem Soc Trans. 2007 Dec;35(Pt 6):1643-7. (PMID: 18031283)
      RNA Biol. 2013 Nov;10(11):1679-88. (PMID: 24270388)
      Annu Rev Plant Biol. 2014;65:415-42. (PMID: 24471833)
      FEBS J. 2018 Feb;285(3):614-628. (PMID: 29247468)
      Mol Biochem Parasitol. 2001 Jun;115(1):109-17. (PMID: 11377745)
      Cell. 1990 Jan 26;60(2):189-98. (PMID: 1688737)
      Plant J. 2020 Mar;101(5):1040-1056. (PMID: 31630458)
      J Biol Chem. 2002 May 10;277(19):16952-9. (PMID: 11859084)
      EMBO J. 2008 Jun 4;27(11):1596-608. (PMID: 18464794)
      Mol Biochem Parasitol. 2006 Jul;148(1):69-78. (PMID: 16600399)
      Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10323-E10332. (PMID: 30333188)
      EMBO J. 2017 Aug 15;36(16):2435-2454. (PMID: 28684539)
      Nucleic Acids Res. 2008 Jan;36(1):319-29. (PMID: 18032430)
      RNA. 2009 Apr;15(4):588-99. (PMID: 19228586)
      Mol Biochem Parasitol. 1991 Oct;48(2):139-49. (PMID: 1837067)
      Mol Cell. 2020 Aug 20;79(4):629-644.e4. (PMID: 32679035)
      Nat Commun. 2014 Dec 17;5:5729. (PMID: 25517350)
      Mol Cell Proteomics. 2008 Jul;7(7):1286-96. (PMID: 18364347)
      Mol Cell Biol. 2007 Oct;27(19):6876-88. (PMID: 17646387)
      Mol Biochem Parasitol. 1997 Dec 1;90(1):81-94. (PMID: 9497034)
      Plant Cell Physiol. 2019 Apr 1;60(4):862-874. (PMID: 30605550)
      Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2102-2107. (PMID: 29440423)
      Cell Rep. 2012 Jul 26;2(1):19-25. (PMID: 22840392)
      Parasitology. 2019 Jan;146(1):1-27. (PMID: 29898792)
      RNA Biol. 2013;10(9):1495-500. (PMID: 24055869)
      Int J Parasitol. 2018 Feb;48(2):179-189. (PMID: 29100810)
      Mol Cell Biol. 1992 Jan;12(1):56-67. (PMID: 1370342)
    • Grant Information:
      R01 AI091914 United States AI NIAID NIH HHS; R01 AI101057 United States AI NIAID NIH HHS; R01 AI113157 United States AI NIAID NIH HHS
    • Contributed Indexing:
      Keywords: RNA editing; RNA stability; mitochondria; pentatricopeptide proteins; polyadenylation; translation; trypanosome
    • Accession Number:
      0 (Protozoan Proteins)
      0 (RNA, Mitochondrial)
      0 (RNA, Protozoan)
      63231-63-0 (RNA)
    • Publication Date:
      Date Created: 20201217 Date Completed: 20211210 Latest Revision: 20230103
    • Publication Date:
      20231215
    • Accession Number:
      PMC9805618
    • Accession Number:
      10.1002/wrna.1638
    • Accession Number:
      33331073