Menu
×
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. - 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Natriuretic Effect of Two Weeks of Dapagliflozin Treatment in Patients With Type 2 Diabetes and Preserved Kidney Function During Standardized Sodium Intake: Results of the DAPASALT Trial.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Scholtes RA;Scholtes RA; Muskiet MHA; Muskiet MHA; van Baar MJB; van Baar MJB; Hesp AC; Hesp AC; Greasley PJ; Greasley PJ; Karlsson C; Karlsson C; Hammarstedt A; Hammarstedt A; Arya N; Arya N; van Raalte DH; van Raalte DH; Heerspink HJL; Heerspink HJL
- Source:
Diabetes care [Diabetes Care] 2021 Feb; Vol. 44 (2), pp. 440-447. Date of Electronic Publication: 2020 Dec 14.- Publication Type:
Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
- Publication Information: Publication: Alexandria Va : American Diabetes Association
Original Publication: New York, American Diabetes Assn. - Subject Terms:
- Abstract: Objective: Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk for heart failure hospitalization potentially by inducing sodium excretion, osmotic diuresis, and plasma volume contraction. Few studies have investigated this hypothesis, but none have assessed cumulative sodium excretion with SGLT2 inhibition during standardized sodium intake in patients with type 2 diabetes.
Research Design and Methods: The DAPASALT trial was a mechanistic, nonrandomized, open-label study in patients with type 2 diabetes with preserved kidney function on a controlled standardized sodium diet (150 mmol/day). It evaluated the effects of dapagliflozin on sodium excretion, 24-h blood pressure, and extracellular, intracellular, and plasma volumes at the start of treatment (ST) (days 2-4), end of treatment (ET) (days 12-14), and follow-up (FU) (days 15-18).
Results: Fourteen patients were included in the efficacy analysis. Mean (SD) baseline sodium excretion (150 [32] mmol/24-h) did not significantly change during treatment (change at ST: -7.0 mmol/24-h [95% CI -22.4, 8.4]; change at ET: 2.1 mmol/24-h [-28.8, 33.0]). Mean baseline 24-h systolic blood pressure was 128 (10) mmHg and significantly reduced at ST (-6.1 mmHg [-9.1, -3.1]; P < 0.001) and ET (-7.2 mmHg [-10.0, -4.3]; P < 0.001). Dapagliflozin did not significantly alter plasma volume or intracellular volume, while extracellular volume changed at ST (-0.7 L [-1.3, -0.1]; P = 0.02). As expected, 24-h urinary glucose excretion significantly increased during dapagliflozin treatment and reversed during FU.
Conclusions: During standardized sodium intake, dapagliflozin reduced blood pressure without clear changes in urinary sodium excretion, suggesting that factors other than natriuresis and volume changes may contribute to the blood pressure-lowering effects.
(© 2020 by the American Diabetes Association.) - References: Nat Rev Nephrol. 2021 Jan;17(1):65-77. (PMID: 33005037)
N Engl J Med. 2020 Oct 8;383(15):1436-1446. (PMID: 32970396)
Adv Ther. 2017 Feb;34(2):436-451. (PMID: 27981497)
N Engl J Med. 2017 Aug 17;377(7):644-657. (PMID: 28605608)
Diabet Med. 2010 Feb;27(2):136-42. (PMID: 20546255)
J Clin Med. 2019 May 31;8(6):. (PMID: 31159350)
J Clin Invest. 2017 May 1;127(5):1932-1943. (PMID: 28414302)
J Am Heart Assoc. 2020 May 5;9(9):e015716. (PMID: 32326806)
Diabetes Care. 2018 Feb;41(2):356-363. (PMID: 29203583)
Adv Ther. 2015 Aug;32(8):768-82. (PMID: 26280756)
J Hypertens. 2020 Sep;38(9):1811-1819. (PMID: 32516291)
Hypertension. 2015 Oct;66(4):850-7. (PMID: 26259596)
Physiol Meas. 2008 Jul;29(7):761-70. (PMID: 18560058)
Lancet. 2019 Jan 5;393(10166):31-39. (PMID: 30424892)
Diabetes Obes Metab. 2015 Dec;17(12):1180-93. (PMID: 26343814)
Mol Cell Biochem. 2019 Sep;459(1-2):121-130. (PMID: 31127491)
J Appl Physiol (1985). 2007 Mar;102(3):1235-42. (PMID: 17110515)
J Am Heart Assoc. 2018 Feb 10;7(4):. (PMID: 29440005)
N Engl J Med. 2019 Jan 24;380(4):347-357. (PMID: 30415602)
PLoS One. 2014 Aug 26;9(8):e105754. (PMID: 25157616)
JCI Insight. 2018 Apr 19;3(8):. (PMID: 29669938)
Diabetologia. 2018 Oct;61(10):2108-2117. (PMID: 30132036)
N Engl J Med. 2015 Nov 26;373(22):2117-28. (PMID: 26378978)
J Clin Invest. 2017 May 1;127(5):1944-1959. (PMID: 28414295)
Cardiovasc Diabetol. 2014 Jan 29;13:28. (PMID: 24475922)
Diabetes Obes Metab. 2018 Mar;20(3):479-487. (PMID: 29024278)
PLoS One. 2014 Aug 28;9(8):e105638. (PMID: 25166023)
Am J Med Sci. 2016 Nov;352(5):517-523. (PMID: 27865300)
Diabetes Obes Metab. 2013 Sep;15(9):853-62. (PMID: 23668478)
Circulation. 2020 Nov 3;142(18):1713-1724. (PMID: 32865004)
Circulation. 2020 Sep 15;142(11):1028-1039. (PMID: 32410463)
Cardiovasc Diabetol. 2017 Oct 23;16(1):138. (PMID: 29061124)
Ann Med. 2012 Jun;44 Suppl 1:S143-8. (PMID: 22471931)
J Pharmacol Exp Ther. 2020 Oct;375(1):76-91. (PMID: 32764153)
Clin J Am Soc Nephrol. 2017 Apr 3;12(4):700-710. (PMID: 28254770)
JACC Basic Transl Sci. 2020 Jan 29;5(2):169-179. (PMID: 32140623)
Circulation. 2017 Sep 19;136(12):1167-1169. (PMID: 28923906)
Diabetes Obes Metab. 2013 Jul;15(7):613-21. (PMID: 23356556) - Molecular Sequence: ClinicalTrials.gov NCT03152084
figshare 10.2337/figshare.13232276 - Accession Number: 0 (Benzhydryl Compounds)
0 (Blood Glucose)
0 (Glucosides)
0 (Natriuretic Agents)
0 (Sodium, Dietary)
0 (Sodium-Glucose Transporter 2 Inhibitors)
1ULL0QJ8UC (dapagliflozin) - Publication Date: Date Created: 20201215 Date Completed: 20210820 Latest Revision: 20220322
- Publication Date: 20221213
- Accession Number: PMC7818331
- Accession Number: 10.2337/dc20-2604
- Accession Number: 33318125
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.