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A Meta-Analysis of the Impact of Resveratrol Supplementation on Markers of Renal Function and Blood Pressure in Type 2 Diabetic Patients on Hypoglycemic Therapy.
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- Author(s): Nyambuya TM;Nyambuya TM;Nyambuya TM; Nkambule BB; Nkambule BB; Mazibuko-Mbeje SE; Mazibuko-Mbeje SE; Mxinwa V; Mxinwa V; Mokgalaboni K; Mokgalaboni K; Orlando P; Orlando P; Silvestri S; Silvestri S; Louw J; Louw J; Louw J; Tiano L; Tiano L; Dludla PV; Dludla PV; Dludla PV
- Source:
Molecules (Basel, Switzerland) [Molecules] 2020 Nov 30; Vol. 25 (23). Date of Electronic Publication: 2020 Nov 30.- Publication Type:
Journal Article; Meta-Analysis- Language:
English - Source:
- Additional Information
- Source: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
- Publication Information: Original Publication: Basel, Switzerland : MDPI, c1995-
- Subject Terms: Dietary Supplements*; Biomarkers/*analysis ; Cardiovascular Diseases/*prevention & control ; Diabetes Mellitus, Type 2/*drug therapy ; Hypoglycemic Agents/*administration & dosage ; Kidney Diseases/*prevention & control ; Resveratrol/*therapeutic use; Antioxidants/therapeutic use ; Blood Pressure ; Drug Therapy, Combination ; Humans ; Kidney Function Tests
- Abstract: Evidence on the beneficial effects of resveratrol supplementation on cardiovascular disease-related profiles in patients with type 2 diabetes (T2D) is conflicting, while its impact on renal function and blood pressure measurements remains to be established in these patients. The current meta-analysis included randomized controlled trials (RCTs) reporting on the impact of resveratrol supplementation on markers of renal function and blood pressure in patients with T2D on hypoglycemic medication. Electronic databases such as MEDLINE, Cochrane Library, Scopus, and EMBASE were searched for eligible studies from inception up to June 2020. The random and fixed effects model was used in the meta-analysis. A total of five RCTs met the inclusion criteria and involved 388 participants with T2D. Notably, most of the participants were on metformin therapy, or metformin in combination with other hypoglycemic drugs such as insulin and glibenclamide. Pooled estimates showed that resveratrol supplementation in patients with T2D lowered the levels of fasting glucose (SMD: -0.06 [95% CI: -0.24, 0.12]; I 2 = 4%, p = 0.39) and insulin (SMD: -0.08 [95% CI: -0.50, 0.34], I 2 = 73%, p = 0.002) when compared to those on placebo. In addition, supplementation significantly lowered systolic blood pressure (SMD: -5.77 [95% CI: -8.61, -2.93], I 2 = 66%, p = 0.02) in these patients. Although resveratrol supplementation did not affect creatinine or urea levels, it reduced the total protein content (SMD: -0.19 [95% CI: -0.36, -0.02]; I 2 = 91%, p = 0.001). In all, resveratrol supplementation in hypoglycemic therapy improves glucose control and lowers blood pressure; however, additional evidence is necessary to confirm its effect on renal function in patients with T2D.
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- Contributed Indexing: Keywords: blood pressure; diabetic complications; hypoglycemic therapy; metabolic syndrome; metformin; polyphenols; renal function; resveratrol; type 2 diabetes
- Accession Number: 0 (Antioxidants)
0 (Biomarkers)
0 (Hypoglycemic Agents)
Q369O8926L (Resveratrol) - Publication Date: Date Created: 20201203 Date Completed: 20210408 Latest Revision: 20240331
- Publication Date: 20240331
- Accession Number: PMC7730696
- Accession Number: 10.3390/molecules25235645
- Accession Number: 33266114
- Source:
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