Emerging role of CCN family proteins in fibrosis.

Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE

Publication: New York, NY : Wiley-Liss
Original Publication: Philadelphia, Wistar Institute of Anatomy and Biology.

CCN Intercellular Signaling Proteins/*metabolism ; Extracellular Matrix/*metabolism; Animals ; Cardiomyopathies/metabolism ; Cardiomyopathies/pathology ; Extracellular Matrix/pathology ; Fibrosis ; Humans ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Signal Transduction ; Wound Healing

Fibrosis is a common pathological change characterized by the excessive accumulation of fibrous connective tissue. Once uncontrolled, this pathological progress can lead to irreversible damage to the structure and function of organs, which is a serious threat to human health and life. Actually, the disability and death of patients caused by many chronic diseases have a closed relationship with fibrosis. The CCN protein family, including six members, is a small group of matrix proteins exhibiting structurally similar features. In the past 20 years, different biological functions of CCN proteins have been identified in various diseases. Of note, it has been recently shown that they are implicated in the key pathological process of fibrosis. In this review, we summarize the current status of knowledge regarding the role of CCN proteins involved in the pathogenesis of fibrosis diseases in detail. Furthermore, we highlight some of the underlying interaction mechanisms of CCN protein acting in fibrosis that helps to develop new drugs and determine appropriate clinical strategies for fibrotic diseases.
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Keywords: CCN protein; TGF-β; extracellular matrix; fibrosis; myofibroblasts

0 (CCN Intercellular Signaling Proteins)

Date Created: 20201122 Date Completed: 20211004 Latest Revision: 20211004

20240829

10.1002/jcp.30171

33222181