Detection and Characterization of Bat Sarbecovirus Phylogenetically Related to SARS-CoV-2, Japan.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
    • Subject Terms:
      Betacoronavirus/*genetics ; Chiroptera/*virology ; Coronavirus Infections/*veterinary; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Betacoronavirus/physiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; HEK293 Cells ; Humans ; Japan/epidemiology ; Phylogeny ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
    • Abstract:
      Epidemiology of bat Betacoronavirus, subgenus Sarbecovirus is largely unknown, especially outside China. We detected a sarbecovirus phylogenetically related to severe acute respiratory syndrome coronavirus 2 from Rhinolophus cornutus bats in Japan. The sarbecovirus' spike protein specifically recognizes angiotensin-converting enzyme 2 of R. cornutus, but not humans, as an entry receptor.
    • References:
      Nature. 2020 Mar;579(7798):270-273. (PMID: 32015507)
      Science. 2003 Oct 10;302(5643):276-8. (PMID: 12958366)
      Microbiol Resour Announc. 2019 Jul 11;8(28):. (PMID: 31296683)
      J Virol. 2011 May;85(9):4122-34. (PMID: 21325420)
      J Vet Med Sci. 2014 Sep;76(9):1267-9. (PMID: 24871548)
      Curr Biol. 2020 Apr 6;30(7):1346-1351.e2. (PMID: 32197085)
      Mol Phylogenet Evol. 2010 Jan;54(1):1-9. (PMID: 19766726)
      Nature. 2020 May;581(7807):215-220. (PMID: 32225176)
      PLoS Pathog. 2017 Nov 30;13(11):e1006698. (PMID: 29190287)
      Emerg Infect Dis. 2020 Jul;26(7):1542-1547. (PMID: 32315281)
      Nature. 2013 Nov 28;503(7477):535-8. (PMID: 24172901)
      Viruses. 2020 Jun 10;12(6):. (PMID: 32532094)
      J Virol. 2015 Dec 30;90(6):3253-6. (PMID: 26719272)
      Nat Microbiol. 2020 Apr;5(4):562-569. (PMID: 32094589)
      J Virol. 2010 Nov;84(21):11336-49. (PMID: 20686038)
    • Contributed Indexing:
      Keywords: COVID-19; Japan; Rhinolophus cornutus; SARS; SARS-CoV-2; bat sarbecovirus; betacoronavirus; coronavirus; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses
    • Accession Number:
      0 (Spike Glycoprotein, Coronavirus)
      0 (spike protein, SARS-CoV-2)
      EC 3.4.17.23 (Angiotensin-Converting Enzyme 2)
    • Publication Date:
      Date Created: 20201121 Date Completed: 20201204 Latest Revision: 20201214
    • Publication Date:
      20231215
    • Accession Number:
      PMC7706965
    • Accession Number:
      10.3201/eid2612.203386
    • Accession Number:
      33219796