Epidemiology of diabetes among South Asians in the United States: lessons from the MASALA study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Gujral UP;Gujral UP; Kanaya AM; Kanaya AM
  • Source:
    Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Jul; Vol. 1495 (1), pp. 24-39. Date of Electronic Publication: 2020 Nov 20.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: New York Academy of Sciences Country of Publication: United States NLM ID: 7506858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1749-6632 (Electronic) Linking ISSN: 00778923 NLM ISO Abbreviation: Ann N Y Acad Sci Subsets: MEDLINE
    • Publication Information:
      Publication: 2006- : New York, NY : Malden, MA : New York Academy of Sciences ; Blackwell
      Original Publication: New York, The Academy.
    • Subject Terms:
      Asian/*statistics & numerical data ; Diabetes Mellitus, Type 2/*epidemiology ; Insulin Resistance/*physiology; Atherosclerosis/pathology ; Body Composition ; Cultural Characteristics ; Diet ; Humans ; Insulin Secretion/physiology ; Risk Factors ; United States/epidemiology
    • Abstract:
      South Asian individuals in the United States are at an increased risk of type 2 diabetes (T2DM); however, the mechanisms behind this are not well understood. The Mediators of Atherosclerosis in South Asians Living in America (MASALA) study is the only longitudinal cohort of South Asians in the United States and provides key insights as to the epidemiology of T2DM in South Asians. Evidence from the MASALA study suggests that South Asians experience a disproportionately high burden of prevalent and incident T2DM compared with members of other race/ethnic groups. Higher insulin resistance in South Asians, even with low body mass index (BMI), more impairment in insulin secretion, and greater deposition of ectopic fat likely play a role in T2DM etiology. Furthermore, South Asian migrants to the United States experience a range of factors related to acculturation, social networks, and religious beliefs, which may impact physical activity and dietary practices. Interventions to prevent T2DM in South Asians should include a focus on cultural factors related to health and should consider the complete mechanistic pathway and the relative contributions of insulin resistance, β cell dysfunction, and ectopic fat deposition on T2DM development in South Asians, particularly in those with lower BMI.
      (© 2020 New York Academy of Sciences.)
    • References:
      J Nutr. 2018 Dec 1;148(12):1954-1960. (PMID: 30418560)
      Diabetes. 2009 Nov;58(11):2429-43. (PMID: 19875619)
      J Health Psychol. 1997 Jul;2(3):335-51. (PMID: 22013026)
      Am J Clin Nutr. 2014 Jul;100 Suppl 1:359S-64S. (PMID: 24847857)
      J Nutr. 2015 Jun;145(6):1211-7. (PMID: 25904730)
      Diabetologia. 2020 Jun;63(6):1103-1109. (PMID: 32236731)
      Lancet. 2004 Jan 10;363(9403):157-63. (PMID: 14726171)
      Ethn Health. 2022 Apr;27(3):639-657. (PMID: 32122159)
      Soc Sci Med. 1999 Sep;49(6):781-9. (PMID: 10459889)
      JAMA. 2019 Dec 24;322(24):2389-2398. (PMID: 31860047)
      J Am Coll Nutr. 2010 Apr;29(2):130-5. (PMID: 20679148)
      J Aging Phys Act. 2015 Apr;23(2):323-9. (PMID: 24911115)
      N Engl J Med. 1991 Jul 18;325(3):147-52. (PMID: 2052059)
      J Nutr Educ Behav. 2017 Nov - Dec;49(10):872-876.e1. (PMID: 28919135)
      Diabetes Care. 2009 Sep;32(9):1678-83. (PMID: 19502541)
      J Nutr. 2018 Jul 1;148(7):1150-1159. (PMID: 29893901)
      Am J Public Health. 2010 Apr;100(4):661-8. (PMID: 19608956)
      Prev Med. 2005 Jun;40(6):831-41. (PMID: 15850885)
      Diabetes Care. 2011 Aug;34(8):1741-8. (PMID: 21680722)
      Int J Behav Nutr Phys Act. 2017 Apr 27;14(1):56. (PMID: 28449673)
      J Phys Act Health. 2019 Dec 6;17(2):149-155. (PMID: 31810059)
      Psychol Bull. 2009 Jul;135(4):531-54. (PMID: 19586161)
      Diabetes Metab Res Rev. 2017 Jul;33(5):. (PMID: 28224756)
      J Womens Health Gend Based Med. 1999 Jul-Aug;8(6):805-13. (PMID: 10495261)
      Diabetes Care. 2013 Jun;36(6):1789-96. (PMID: 23704681)
      Diabetes Care. 2015 May;38(5):814-20. (PMID: 25665815)
      Biomed Pharmacother. 2004 Dec;58(10):571-7. (PMID: 15589065)
      Br J Nutr. 2009 Nov;102(10):1498-506. (PMID: 19586573)
      Diabetes Res Clin Pract. 2019 Jul;153:93-102. (PMID: 31150721)
      Nutrition. 2016 Sep;32(9):975-84. (PMID: 27155957)
      Biomark Res. 2015 Oct 13;3:22. (PMID: 26966540)
      Diabetologia. 2018 Jul;61(7):1495-1502. (PMID: 29744538)
      J Diabetes Complications. 2014 Jan-Feb;28(1):45-50. (PMID: 24211090)
      Obes Med. 2018 Mar;9:1-6. (PMID: 29354780)
      Diabetes Care. 2011 Aug;34(8):1791-3. (PMID: 21715521)
      Diabet Med. 2004 Apr;21(4):349-53. (PMID: 15049937)
      Diabetes Care. 2014 Jun;37(6):1621-8. (PMID: 24705613)
      J Immigr Minor Health. 2011 Feb;13(1):1-8. (PMID: 19688263)
      Diabetologia. 2006 Feb;49(2):289-97. (PMID: 16391903)
      Nutrients. 2017 Sep 06;9(9):. (PMID: 28878172)
      Diabetes Care. 2019 May;42(5):946-953. (PMID: 30796111)
      PLoS One. 2011;6(7):e22112. (PMID: 21829446)
      Diabet Med. 2021 Feb;38(2):e14494. (PMID: 33617033)
      J Clin Invest. 2006 Jul;116(7):1756-60. (PMID: 16823472)
      Diabetes Care. 2015 Aug;38(8):1441-8. (PMID: 25906786)
      Rev Environ Health. 2008 Jan-Mar;23(1):59-74. (PMID: 18557598)
      Environ Health Perspect. 2013 Jul;121(7):774-83. (PMID: 23651634)
      Ann Epidemiol. 2015 Feb;25(2):77-83. (PMID: 25459085)
      J Am Diet Assoc. 2003 Sep;103(9):1178-84. (PMID: 12963948)
      Ann Intern Med. 2017 May 02;166(9):628-636. (PMID: 28384781)
      Diabetes Care. 2011 Feb;34(2):497-503. (PMID: 21270206)
      J Clin Transl Sci. 2019 May 27;3(2-3):97-104. (PMID: 31660232)
      Diabetes. 2005 Jan;54(1):158-65. (PMID: 15616024)
      Am J Epidemiol. 2002 Nov 1;156(9):871-81. (PMID: 12397006)
      Diabetes Care. 2015 Jan;38(1):150-8. (PMID: 25538311)
      J Epidemiol Community Health. 2011 Jun;65(6):517-21. (PMID: 20525752)
      Diabetes Obes Metab. 2018 Mar;20(3):667-671. (PMID: 29077244)
      Diabetes Educ. 2004 Nov-Dec;30(6):980-93. (PMID: 15641619)
      Diabetes Care. 2016 Oct;39(10):1760-7. (PMID: 27504014)
      Wiley Interdiscip Rev RNA. 2014 Sep-Oct;5(5):697-712. (PMID: 24944010)
      Cell Metab. 2009 Apr;9(4):311-26. (PMID: 19356713)
      Chest. 2008 Feb;133(2):496-506. (PMID: 18252916)
      Diabetes Res Clin Pract. 2020 Mar;161:108052. (PMID: 32113027)
      Nat Med. 2011 Apr;17(4):448-53. (PMID: 21423183)
      Fam Community Health. 2013 Oct-Dec;36(4):311-23. (PMID: 23986072)
      Am J Clin Nutr. 2003 Sep;78(3 Suppl):610S-616S. (PMID: 12936955)
      Am J Prev Med. 2008 Jul;35(1):38-46. (PMID: 18541175)
      J Sci Food Agric. 2015 Oct;95(13):2567-70. (PMID: 25640072)
      Am J Respir Crit Care Med. 2005 Dec 15;172(12):1590-5. (PMID: 16192452)
      Am J Med. 1991 Feb;90(2):229-35. (PMID: 1996593)
      Diabetes Care. 2018 Jan;41(Suppl 1):S13-S27. (PMID: 29222373)
      Int J Obes (Lond). 2016 Apr;40(4):639-45. (PMID: 26499444)
      J Diabetes Complications. 2014 Jul-Aug;28(4):500-5. (PMID: 24581791)
      Environ Sci Technol. 2019 Dec 3;53(23):13906-13918. (PMID: 31746186)
      Diabet Med. 2007 Nov;24(11):1199-204. (PMID: 17725630)
      Ann N Y Acad Sci. 2013 Apr;1281:51-63. (PMID: 23317344)
      Lancet Diabetes Endocrinol. 2017 Aug;5(8):585-596. (PMID: 28601585)
      Diabetes Care. 2010 Apr;33(4):804-10. (PMID: 20097779)
      Diabetes. 2009 Dec;58(12):2718-25. (PMID: 19940235)
      Clin Cardiol. 2013 Dec;36(12):713-720. (PMID: 24194499)
      Br J Nutr. 2009 Feb;101(4):465-73. (PMID: 18842159)
      Ethn Health. 1996 Mar;1(1):47-53. (PMID: 9395547)
      Diabetologia. 2003 Jan;46(1):3-19. (PMID: 12637977)
      Diabetes Care. 2007 Mar;30(3):744-52. (PMID: 17327354)
      Environ Int. 2014 May;66:48-64. (PMID: 24525153)
      Am J Med. 2009 Dec;122(12):1122-7. (PMID: 19958890)
      Ann Intern Med. 1999 Oct 5;131(7):485-91. (PMID: 10507956)
      Am J Public Health. 2014 Apr;104 Suppl 2:S234-50. (PMID: 24899459)
      Diabetologia. 2003 Aug;46(8):1063-70. (PMID: 12827246)
      Am J Prev Med. 2013 Aug;45(2):158-66. (PMID: 23867022)
      Nutr J. 2013 Dec 11;12:158. (PMID: 24330454)
      Diabetes Care. 2015 Jul;38(7):1312-8. (PMID: 25877810)
      J Immigr Minor Health. 2017 Apr;19(2):373-380. (PMID: 26928020)
      BMC Med. 2014 Aug 26;12:123. (PMID: 25159817)
      BMJ Open Diabetes Res Care. 2020 Jul;8(1):. (PMID: 32646924)
      J Phys Act Health. 2016 May;13(5):514-9. (PMID: 26529292)
      Nat Rev Endocrinol. 2009 Jul;5(7):401-8. (PMID: 19488075)
      J Relig Health. 2018 Feb;57(1):33-46. (PMID: 27460674)
    • Grant Information:
      R01HL093009 United States HL NHLBI NIH HHS; UL1RR024131 Foundation for the National Institutes of Health; UL1 TR001872 United States TR NCATS NIH HHS; P30-DK-111024 United States DK NIDDK NIH HHS; M01 RR001271 United States RR NCRR NIH HHS; K24 HL112827 United States HL NHLBI NIH HHS; P30 DK098722 United States DK NIDDK NIH HHS; P30 DK092924 United States DK NIDDK NIH HHS; UL1TR001872 Foundation for the National Institutes of Health; R01 HL120725 United States HL NHLBI NIH HHS; P30 DK111024 United States DK NIDDK NIH HHS; R01 HL093009 United States HL NHLBI NIH HHS; UL1 RR024131 United States RR NCRR NIH HHS; R01HL120725 United States RR NCRR NIH HHS; P30-DK-111024 United States DK NIDDK NIH HHS; R01HL120725 United States RR NCRR NIH HHS; R01HL093009 United States HL NHLBI NIH HHS
    • Contributed Indexing:
      Keywords: BMI; MASALA; South Asian; ethnicity; insulin resistance; the United States; type 2 diabetes
    • Publication Date:
      Date Created: 20201120 Date Completed: 20211116 Latest Revision: 20240402
    • Publication Date:
      20240402
    • Accession Number:
      PMC8134616
    • Accession Number:
      10.1111/nyas.14530
    • Accession Number:
      33216378