The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Food*; Asthma/*pathology ; Histamine/*adverse effects; Child ; Diet ; Feeding Behavior ; Female ; Humans ; Male ; Micronutrients/analysis ; Pilot Projects

Asthma is a complex chronic inflammatory disorder. Diet's impact on asthma symptoms is controversial. The objective of this pilot crossover, randomized, two-period study was to examine the effect of dietary histamine intake on asthma symptoms in twenty-one children with mild intermittent asthma. Children were randomly assigned to either a high- or low-histamine diet, based on the Mediterranean pattern, for 4 weeks. After a 2-week washout period, patients crossed to the alternative diet for 4 additional weeks. Asthma symptoms were assessed at baseline and after the completion of each diet period by a clinician. Daily symptoms and peak flow were recorded throughout the intervention. Adherence to the dietary intervention was assessed via analysis of four random 24-h recalls, for each intervention period. Eighteen children completed the study. Significantly higher mean air flow obstruction was recorded and a trend for prolonged and more severe symptoms was observed during the high-histamine period. Diet may have an active and direct impact on asthma symptoms. Food choice is affected and/or may affect symptoms in children with mild asthma. Diet intervention is promising yet challenging, for asthma control.

Thorax. 2009 Jul;64(7):610-9. (PMID: 19406861)
Breathe (Sheff). 2019 Jun;15(2):e50-e61. (PMID: 31777565)
East Mediterr Health J. 2014 Jun 18;20(6):391-6. (PMID: 24960516)
Foods. 2018 Dec 14;7(12):. (PMID: 30558197)
J Nutr Sci. 2016 Jul 11;5:e29. (PMID: 27547392)
Allergy. 2012 Aug;67(8):976-97. (PMID: 22702533)
Contemp Clin Trials. 2013 Jul;35(2):55-67. (PMID: 23648395)
Cochrane Database Syst Rev. 2016 Oct 28;10:CD010112. (PMID: 27788565)
Pediatrics. 2012 Oct;130(4):674-82. (PMID: 22945403)
EBioMedicine. 2019 Aug;46:399-410. (PMID: 31399385)
Int J Mol Sci. 2019 Apr 08;20(7):. (PMID: 30965592)
Allergo J Int. 2017;26(2):72-79. (PMID: 28344921)
Indian J Pediatr. 2014 Jul;81(7):650-4. (PMID: 24193954)
Allergol Immunopathol (Madr). 2016 Mar-Apr;44(2):99-105. (PMID: 26278484)
Nutrients. 2017 Nov 08;9(11):. (PMID: 29117118)
Allergol Immunopathol (Madr). 2016 Sep-Oct;44(5):475-83. (PMID: 27590961)
Thorax. 1994 Feb;49(2):171-4. (PMID: 8128408)
PLoS One. 2017 Jul 13;12(7):e0180068. (PMID: 28704419)
J Allergy Clin Immunol. 2016 Nov;138(5):1491-1494.e7. (PMID: 27576125)
Ann Dermatol. 2017 Dec;29(6):706-714. (PMID: 29200758)
Clin Exp Allergy. 1993 Dec;23(12):982-5. (PMID: 10779289)
Eur J Clin Nutr. 2005 Jan;59(1):8-15. (PMID: 15329676)
Public Health Nutr. 2009 Sep;12(9):1408-12. (PMID: 19087384)
Pediatr Allergy Immunol Pulmonol. 2017 Dec 1;30(4):202-209. (PMID: 29279788)
Adv Exp Med Biol. 2010;709:53-66. (PMID: 21618887)
Am J Clin Nutr. 2013 Jan;97(1):173-8. (PMID: 23193002)
Am J Clin Nutr. 2007 May;85(5):1185-96. (PMID: 17490952)
J Allergy Clin Immunol. 2014 May;133(5):1255-64. (PMID: 24613565)
Pediatr Allergy Immunol. 2016 Jun;27(4):404-12. (PMID: 26845753)
Am J Clin Nutr. 1995 Jun;61(6 Suppl):1402S-1406S. (PMID: 7754995)
J Allergy Clin Immunol Pract. 2017 May - Jun;5(3):790-796.e1. (PMID: 27913247)
Lancet. 2018 Jan 27;391(10118):350-400. (PMID: 28911920)
Eur J Clin Nutr. 2015 Mar;69(3):303-8. (PMID: 25117998)
J Allergy Clin Immunol. 2013 Jan;131(1):87-93.e1-5. (PMID: 23199600)

Keywords: Mediterranean diet; Western diet; anti-inflammatory diet; antioxidants; asthma; food histamine; nutritional intervention

0 (Micronutrients)
820484N8I3 (Histamine)

Date Created: 20201110 Date Completed: 20210407 Latest Revision: 20231112

20231112

PMC7694530

10.3390/nu12113402

33167542