Discrimination of alcohol dependence based on the convolutional neural network.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Neural Networks, Computer*; Alcoholism/*diagnosis; Adult ; Age Factors ; Alcoholism/genetics ; Educational Status ; Female ; Genotype ; Humans ; Linear Models ; Male ; Marital Status ; Middle Aged ; Support Vector Machine ; Young Adult
    • Abstract:
      In this paper, a total of 20 sites of single nucleotide polymorphisms (SNPs) on the serotonin 3 receptor A gene (HTR3A) and B gene (HTR3B) are used for feature fusion with age, education and marital status information, and the grid search-support vector machine (GS-SVM), the convolutional neural network (CNN) and the convolutional neural network combined with long and short-term memory (CNN-LSTM) are used to classify and discriminate between alcohol-dependent patients (AD) and the non-alcohol-dependent control group. The results show that 19 SNPs combined with academic qualifications have the best discrimination effect. In the GS-SVM, the area under the receiver operating characteristic (ROC) curve (AUC) is 0.87, the AUC of CNN-LSTM is 0.88, and the performance of the CNN model is the best, with an AUC of 0.92. This study shows that the CNN model can more accurately discriminate AD than the SVM to treat patients in time.
      Competing Interests: The authors have declared that no competing interests exist.
    • References:
      Arch Dermatol Res. 2019 May;311(4):309-315. (PMID: 30840133)
      Am J Drug Alcohol Abuse. 2016 May;42(3):316-24. (PMID: 27144979)
      Arch Clin Neuropsychol. 2012 Jun;27(4):433-9. (PMID: 22572055)
      Clin Chem Lab Med. 2003 Apr;41(4):529-34. (PMID: 12747598)
      Subst Use Misuse. 2016 Sep 18;51(11):1451-61. (PMID: 27326749)
      IEEE Trans Pattern Anal Mach Intell. 2017 Jul;39(7):1476-1481. (PMID: 27541490)
      Syst Biol Reprod Med. 2019 Feb;65(1):75-80. (PMID: 29764212)
      J Behav Addict. 2017 Mar 1;6(1):84-91. (PMID: 28316252)
      Transl Psychiatry. 2017 Dec 11;7(12):1279. (PMID: 29225356)
      BMC Public Health. 2018 Mar 16;18(1):364. (PMID: 29548314)
      Open Forum Infect Dis. 2018 Jan 09;5(4):ofy011. (PMID: 29707598)
      BMC Cancer. 2006 May 03;6:114. (PMID: 16672066)
      Alcohol Res Health. 2008;31(3):185-95. (PMID: 19881886)
      Clin Genet. 2017 Jun;91(6):849-858. (PMID: 27883173)
      Hum Genet. 2013 Oct;132(10):1165-76. (PMID: 23757001)
      Comput Biol Med. 2019 Aug;111:103345. (PMID: 31279167)
      Turk J Emerg Med. 2018 Aug 07;18(3):91-93. (PMID: 30191186)
      Magn Reson Chem. 2017 Apr;55(4):318-322. (PMID: 27662108)
      Mol Psychiatry. 2011 Nov;16(11):1139-46. (PMID: 20838391)
      Lancet. 2009 Feb 7;373(9662):492-501. (PMID: 19168210)
      JAMA Psychiatry. 2017 Nov 1;74(11):1153-1160. (PMID: 28813562)
      Hum Genet. 2014 Jul;133(7):905-18. (PMID: 24590108)
      Subst Abuse Treat Prev Policy. 2016 Oct 28;11(1):37. (PMID: 27793173)
      BMC Cardiovasc Disord. 2019 Aug 20;19(1):202. (PMID: 31429711)
      Oncotarget. 2017 Nov 7;8(66):110635-110649. (PMID: 29299175)
      Front Genet. 2017 Oct 31;8:167. (PMID: 29163635)
      Anal Chem. 2000 Jul 15;72(14):3298-302. (PMID: 10939403)
      Addiction. 2005 Mar;100(3):281-92. (PMID: 15733237)
      Transl Psychiatry. 2017 Feb 28;7(2):e1048. (PMID: 28244981)
      Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008 Apr;43(2):87-96. (PMID: 18516948)
      BMC Med Genomics. 2018 Nov 20;11(Suppl 5):105. (PMID: 30453947)
      Lancet Public Health. 2018 Mar;3(3):e124-e132. (PMID: 29475810)
      J Biosci Bioeng. 2002;93(5):470-8. (PMID: 16233234)
      J Hepatol. 2017 Jan;66(1):195-211. (PMID: 27575312)
      J Clin Psychol. 2017 Mar;73(3):319-330. (PMID: 27467499)
      Comput Biol Med. 2018 Nov 1;102:278-287. (PMID: 29903630)
      Biomed Res Int. 2019 Mar 21;2019:1065652. (PMID: 31016181)
      Front Hum Neurosci. 2010 Oct 25;4:192. (PMID: 21119772)
      Psychiatry Res. 2017 May;251:69-75. (PMID: 28189939)
      Indian J Dermatol. 2016 Nov-Dec;61(6):593-601. (PMID: 27904175)
      Hum Mutat. 2017 Feb;38(2):137-147. (PMID: 27763704)
      Addiction. 2019 Sep;114(9):1556-1566. (PMID: 31059161)
      Arch Gen Psychiatry. 2007 Jul;64(7):830-42. (PMID: 17606817)
      Syst Biol Reprod Med. 2019 Jun;65(3):258-263. (PMID: 30977407)
    • Publication Date:
      Date Created: 20201027 Date Completed: 20201215 Latest Revision: 20201215
    • Publication Date:
      20240628
    • Accession Number:
      PMC7591038
    • Accession Number:
      10.1371/journal.pone.0241268
    • Accession Number:
      33108388