Wide awake at bedtime? Effects of caffeine on sleep and circadian timing in male adolescents - A randomized crossover trial.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Elsevier Science
      Original Publication: Oxford, New York [etc.] Paragamon Press.
    • Subject Terms:
      Brain/*drug effects ; Caffeine/*administration & dosage ; Central Nervous System Stimulants/*administration & dosage ; Circadian Rhythm/*drug effects ; Sleep/*drug effects ; Wakefulness/*drug effects; Adolescent ; Brain/diagnostic imaging ; Brain/physiology ; Caffeine/adverse effects ; Caffeine/metabolism ; Central Nervous System Stimulants/adverse effects ; Central Nervous System Stimulants/metabolism ; Circadian Rhythm/physiology ; Cross-Over Studies ; Double-Blind Method ; Humans ; Male ; Melatonin/metabolism ; Saliva/metabolism ; Sleep/physiology ; Wakefulness/physiology
    • Abstract:
      Adolescents often suffer from short and mistimed sleep. To counteract the resulting daytime sleepiness they frequently consume caffeine. However, caffeine intake may exaggerate sleep problems by disturbing sleep and circadian timing. In a 28-hour double-blind randomized crossover study, we investigated to what extent caffeine disturbs slow-wave sleep (SWS) and delays circadian timing in teenagers. Following a 6-day ambulatory phase of caffeine abstinence and fixed sleep-wake cycles, 18 male teenagers (14-17 years old) ingested 80 mg caffeine vs. placebo in the laboratory four hours prior to an electro-encephalographically (EEG) recorded nighttime sleep episode. Data were analyzed using both frequentist and Bayesian statistics. The analyses suggest that subjective sleepiness is reduced after caffeine compared to placebo. However, we did not observe a strong caffeine-induced reduction in subjective sleep quality or SWS, but rather a high inter-individual variability in caffeine-induced SWS changes. Exploratory analyses suggest that particularly those individuals with a higher level of SWS during placebo reduced SWS in response to caffeine. Regarding salivary melatonin onsets, caffeine-induced delays were not evident at group level, and only observed in participants exposed to a higher caffeine dose relative to individual bodyweight (i.e., a dose > 1.3 mg/kg). Together, the results suggest that 80 mg caffeine are sufficient to induce alertness at a subjective level. However, particularly teenagers with a strong need for deep sleep might pay for these subjective benefits by a loss of SWS during the night. Thus, caffeine-induced sleep-disruptions might change along with the maturation of sleep need.
      (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Adolescence; Caffeine; Circadian; Melatonin; Sleep; Sleepiness
    • Accession Number:
      0 (Central Nervous System Stimulants)
      3G6A5W338E (Caffeine)
      JL5DK93RCL (Melatonin)
    • Publication Date:
      Date Created: 20201018 Date Completed: 20211116 Latest Revision: 20211116
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.bcp.2020.114283
    • Accession Number:
      33069664