The effects of quinoa seed supplementation on cardiovascular risk factors: A systematic review and meta-analysis of controlled clinical trials.

Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1573 (Electronic) Linking ISSN: 0951418X NLM ISO Abbreviation: Phytother Res Subsets: MEDLINE

Publication: : Chichester : Wiley
Original Publication: London : Heyden & Son, c1987-

Heart Disease Risk Factors*; Biomarkers/*chemistry ; Cardiovascular Diseases/*drug therapy ; Chenopodium quinoa/*chemistry ; Seeds/*chemistry; Adult ; Humans ; Middle Aged ; Young Adult

This meta-analysis was designed to determine the effect of quinoa seed on cardiovascular disease (CVD) risk factors in adults. PubMed, Scopus, ISI Web of Science, and Cochrane library were searched electronically from their inception to February 2020 to identify eligible RCTs. We calculated the pooled estimates of weighted mean differences (WMDs) and their 95% confidence intervals (CIs) by using random-effects models. Five eligible RCTs representing 206 subjects were enrolled. The pooled result showed that quinoa seed supplementation significantly lowered the body weight (WMD: -1.26 kg, 95% CI: -2.35, -0.18, p = .02), waist circumference (WC) (WMD: -1.15 cm, 95% CI: -2.08, -0.21, p = .01), fat mass (FM) (WMD: -0.59%, 95% CI: -1.14, -0.03, p = .03), insulin serum level (WMD: -0.86 pmol/L, 95% CI: -13.38, -1.59, p = .01), triglyceride (TG) (WMD: -7.20 mg/dl, 95% CI: -9.52, -4.87, p < .001), total cholesterol (TC) (WMD: -6.86 mg/dl, 95% CI: -10.64, -3.08, p < .001), and low density lipoprotein (LDL) (WMD: -3.08 mg/dl, 95% CI: -5.13, -1.03, p = .003) levels. However, no significant changes were seen in other markers (p > .05). The current evidence suggests that quinoa seed might be utilized as a possible new effective and safe supplementary option to better prevent and control CVD in humans.
(© 2020 John Wiley & Sons Ltd.)

Abellán Ruiz, M. S., Barnuevo Espinosa, M. D., García Santamaría, C., Contreras Fernández, C. J., Aldeguer García, M., Soto Méndez, F., … López Román, F. J. (2017). Effect of quinua (Chenopodium quinoa) consumption as a coadjuvant in nutritional intervention in prediabetic subjects. Nutrición Hospitalaria, 34(5), 1163-1169.
Alissa, E. M., & Ferns, G. A. (2017). Dietary fruits and vegetables and cardiovascular diseases risk. Critical Reviews in Food Science and Nutrition, 57(9), 1950-1962.
Anusha, B., Hymavathi, T., Vijayalakshmi, V., Reddy, P., & Robert, T. P. (2018). Lipid-lowering effects of foxtail millet (Setariaitalica) and quinoa (Chenopodium quinoawild) in pre-diabetics. Journal of Pharmaceutical Research International, 24(5), 1-7.
Association, AD. (2017). 9. Cardiovascular disease and risk management. Diabetes Care, 40(Supplement 1), S75-S87.
Bastidas, E., Roura, R., Rizzolo, D., Massanés, T., & Gomis, R. (2016). Quinoa (Chenopodium quinoa Willd), from nutritional value to potential health benefits: An integrative review. Journal of Nutrition & Food Sciences, 6, 3.
Berger, A., Gremaud, G., Baumgartner, M., Rein, D., Monnard, I., Kratky, E., … Lambelet, P. (2003). Cholesterol-lowering properties of amaranth grain and oil in hamsters. International Journal for Vitamin and Nutrition Research, 73(1), 39-47.
Cani, P. D. (2019). Targeting gut microbiota with a complex mix of dietary fibers improves metabolic diseases. Kidney International, 95(1), 14-16.
Cicero, A. F., Colletti, A., Bajraktari, G., Descamps, O., Djuric, D. M., Ezhov, M., … Banach, M. (2017). Lipid-lowering nutraceuticals in clinical practice: Position paper from an international lipid expert panel. Nutrition Reviews, 75(9), 731-767.
De Carvalho, F. G., Ovidio, P. P., Padovan, G. J., Jordao, A. A., Marchini, J. S., & Navarro, A. M. (2014). Metabolic parameters of postmenopausal women after quinoa or corn flakes intake - a prospective and double-blind study. International Journal of Food Sciences and Nutrition, 65(3), 380-385.
Ebrahimi, F., Sahebkar, A., Aryaeian, N., Pahlavani, N., Fallah, S., Moradi, N., … Hosseini, A. F. (2019). Effects of saffron supplementation on inflammation and metabolic responses in type 2 diabetic patients: A randomized, double-blind, placebo-controlled trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 12, 2107-2115.
Escribano, J., Cabanes, J., Jiménez-Atiénzar, M., Ibañez-Tremolada, M., Gómez-Pando, L. R., García-Carmona, F., & Gandía-Herrero, F. (2017). Characterization of betalains, saponins and antioxidant power in differently colored quinoa (Chenopodium quinoa) varieties. Food Chemistry, 234, 285-294.
Escudero, N., Zirulnik, F., Gomez, N., Mucciarelli, S., Mucciarelli, S., & Giménez, M. (2006). Influence of a protein concentrate from Amaranthus cruentus seeds on lipid metabolism. Experimental Biology and Medicine, 231(1), 50-59.
Filho, A. M. M., Pirozi, M. R., Borges, J. T. D. S., Pinheiro Sant'Ana, H. M., Chaves, J. B. P., & Coimbra, J. S. D. R. (2017). Quinoa: Nutritional, functional, and antinutritional aspects. Critical Reviews in Food Science and Nutrition, 57(8), 1618-1630.
Follmann, D., Elliott, P., Suh, I., & Cutler, J. (1992). Variance imputation for overviews of clinical trials with continuous response. Journal of Clinical Epidemiology, 45(7), 769-773.
Foucault, A. S., Mathe, V., Lafont, R., Even, P., Dioh, W., Veillet, S., … Quignard-Boulangé, A. (2012). Quinoa extract enriched in 20-hydroxyecdysone protects mice from diet-induced obesity and modulates adipokines expression. Obesity (Silver Spring), 20(2), 270-277.
Graf, B. L., Poulev, A., Kuhn, P., Grace, M. H., Lila, M. A., & Raskin, I. (2014). Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties. Food Chemistry, 163, 178-185.
Hadi, A., Pourmasoumi, M., Najafgholizadeh, A., Kafeshani, M., & Sahebkar, A. (2019). Effect of purslane on blood lipids and glucose: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy Research, 33(1), 3-12.
Hasani, H., Arab, A., Hadi, A., Pourmasoumi, M., Ghavami, A., & Miraghajani, M. (2019). Does ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials. Phytotherapy Research, 33(6), 1639-1647.
Heilbronn, L. K., & Campbell, L. V. (2008). Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Current Pharmaceutical Design, 14(12), 1225-1230.
Heinrich, M., Appendino, G., Efferth, T., Fürst, R., Izzo, A. A., Kayser, O., … Viljoen, A. (2020). Best practice in research-overcoming common challenges in phytopharmacological research. Journal of Ethnopharmacology, 246, 112230.
Higgins, J. P., Altman, D. G., Gøtzsche, P. C., Jüni, P., Moher, D., Oxman, A. D., … Cochrane Statistical Methods Group. (2011). The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ, 343, d5928.
Howarth, N. C., Saltzman, E., & Roberts, S. B. (2001). Dietary fiber and weight regulation. Nutrition Reviews, 59(5), 129-139.
Kizelsztein, P., Govorko, D., Komarnytsky, S., Evans, A., Wang, Z., Cefalu, W. T., & Raskin, I. (2009). 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. American Journal of Physiology. Endocrinology and Metabolism, 296(3), E433-E439.
Li, L., Lietz, G., Bal, W., Watson, A., Morfey, B., & Seal, C. (2018). Effects of quinoa (Chenopodium quinoa Willd.) consumption on markers of CVD risk. Nutrients, 10(6), 777.
Mann, J. D., Faurot, K. R., MacIntosh, B., Palsson, O. S., Suchindran, C. M., Gaylord, S. A., … Ramsden, C. E. (2018). A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+ DHA in adults with episodic migraine: Study protocol. Prostaglandins, Leukotrienes and Essential Fatty Acids, 128, 41-52.
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Annals of Internal Medicine, 151(4), 264-269.
Navarro-Perez, D., Radcliffe, J., Tierney, A., & Jois, M. (2017). Quinoa seed lowers serum triglycerides in overweight and obese subjects: A dose-response randomized controlled clinical trial. Current Developments in Nutrition, 1(9), e001321.
Navruz-Varli, S., & Sanlier, N. (2016). Nutritional and health benefits of quinoa (Chenopodium quinoa Willd.). Journal of Cereal Science, 69, 371-376.
Noratto, G. D., Murphy, K., & Chew, B. P. (2019). Quinoa intake reduces plasma and liver cholesterol, lessens obesity-associated inflammation, and helps to prevent hepatic steatosis in obese db/db mouse. Food Chemistry, 287, 107-114.
Pahlavani, N., Roudi, F., Zakerian, M., Ferns, G. A., Navashenaq, J. G., Mashkouri, A., … Rahimi, H. (2019). Possible molecular mechanisms of glucose-lowering activities of Momordica charantia (karela) in diabetes. Journal of Cellular Biochemistry, 120(7), 10921-10929.
Paśko, P., Bartoń, H., Zagrodzki, P., Gorinstein, S., Fołta, M., & Zachwieja, Z. (2009). Anthocyanins, total polyphenols and antioxidant activity in amaranth and quinoa seeds and sprouts during their growth. Food Chemistry, 115(3), 994-998.
Pasko, P., Barton, H., Zagrodzki, P., Izewska, A., Krosniak, M., Gawlik, M., … Gorinstein, S. (2010). Effect of diet supplemented with quinoa seeds on oxidative status in plasma and selected tissues of high fructose-fed rats. Plant Foods for Human Nutrition, 65(2), 146-151.
Paśko, P., Zagrodzki, P., Bartoń, H., Chłopicka, J., & Gorinstein, S. (2010). Effect of quinoa seeds (Chenopodium quinoa) in diet on some biochemical parameters and essential elements in blood of high fructose-fed rats. Plant Foods for Human Nutrition, 65(4), 333-338.
Pourmasoumi, M., Hadi, A., Najafgholizadeh, A., Joukar, F., & Mansour-Ghanaei, F. (2020). The effects of cranberry on cardiovascular metabolic risk factors: A systematic review and meta-analysis. Clinical Nutrition, 39(3), 774-788.
Rasad, H., Entezari, M. H., Ghadiri, E., Mahaki, B., & Pahlavani, N. (2018). The effect of honey consumption compared with sucrose on lipid profile in young healthy subjects (randomized clinical trial). Clinical Nutrition ESPEN, 26, 8-12.
Sahebkar, A., Serban, M.-C., Gluba-Brzózka, A., Mikhailidis, D. P., Cicero, A. F., Rysz, J., & Banach, M. (2016). Lipid-modifying effects of nutraceuticals: An evidence-based approach. Nutrition, 32(11-12), 1179-1192.
Satija, A., & Hu, F. B. (2012). Cardiovascular benefits of dietary fiber. Current Atherosclerosis Reports, 14(6), 505-514.
Sezgin, A. C., & Sanlier, N. (2019). A new generation plant for the conventional cuisine: Quinoa (Chenopodium quinoa Willd.). Trends in Food Science & Technology, 86, 51-58.
Simnadis, T. G., Tapsell, L. C., & Beck, E. J. (2015). Physiological effects associated with quinoa consumption and implications for research involving humans: A review. Plant Foods for Human Nutrition, 70(3), 238-249.
Slavin, J., & Green, H. (2007). Dietary fibre and satiety. Nutrition Bulletin, 32, 32-42.
Surampudi, P., Enkhmaa, B., Anuurad, E., & Berglund, L. (2016). Lipid lowering with soluble dietary fiber. Current Atherosclerosis Reports, 18(12), 75.
Takao, T., Watanabe, N., Yuhara, K., Itoh, S., Suda, S., Tsuruoka, Y., … Konishi, Y. (2005). Hypocholesterolemic effect of protein isolated from quinoa (Chenopodium quinoa Willd.) seeds. Food Science and Technology Research, 11(2), 161-167.
Vilcacundo, R., & Hernández-Ledesma, B. (2017). Nutritional and biological value of quinoa (Chenopodium quinoa Willd.). Current Opinion in Food Science, 14, 1-6.
Wilkins, E., Wilson, L., Wickramasinghe, K., Bhatnagar, P., Leal, J., Luengo-Fernandez, R., … Townsend, N. (2017). European Cardiovascular Disease Statistics 2017.
Williamson, E. M., Liu, X., & Izzo, A. A. (2020). Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals. British Journal of Pharmacology, 177(6), 1227-1240.
Yao, Y., Yang, X., Shi, Z., & Ren, G. (2014). Anti-inflammatory activity of saponins from quinoa (Chenopodium quinoa Willd.) seeds in lipopolysaccharide-stimulated RAW 264.7 macrophages cells. Journal of Food Science, 79(5), H1018-H1023.
Yao, Y., Zhu, Y., Gao, Y., Shi, Z., Hu, Y., & Ren, G. (2015). Suppressive effects of saponin-enriched extracts from quinoa on 3T3-L1 adipocyte differentiation. Food & Function, 6(10), 3282-3290.
Zheng, J., Zhou, Y., Li, S., Zhang, P., Zhou, T., Xu, D.-P., & Li, H. B. (2017). Effects and mechanisms of fruit and vegetable juices on cardiovascular diseases. International Journal of Molecular Sciences, 18(3), 555.

Keywords: glycemic control; lipid profile; meta-analysis; quinoa seed; systematic review

0 (Biomarkers)

Date Created: 20201010 Date Completed: 20210430 Latest Revision: 20210430

20240829

10.1002/ptr.6901

33037704