Cardiac magnetic resonance using fused 3D cine and 4D flow sequences:Validation of ventricular and blood flow measurements.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214883 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5894 (Electronic) Linking ISSN: 0730725X NLM ISO Abbreviation: Magn Reson Imaging Subsets: MEDLINE
    • Publication Information:
      Publication: <2008->: Amsterdam : Elsevier
      Original Publication: New York : Pergamon, c1982-
    • Subject Terms:
      Coronary Circulation* ; Magnetic Resonance Imaging, Cine*; Heart Ventricles/*diagnostic imaging ; Heart Ventricles/*physiopathology ; Imaging, Three-Dimensional/*methods; Adult ; Contrast Media ; Female ; Humans ; Male ; Middle Aged ; Respiration ; Retrospective Studies ; Stroke Volume
    • Abstract:
      Purpose: Current cardiovascular magnetic resonance (CMR) examinations require expert planning, multiple breath holds, and 2D imaging. To address this, we sought to develop and validate a comprehensive free-breathing 3D cine function and flow CMR examination using a steady-state free precession (SSFP) sequence to depict anatomy fused with a spatially registered phase contrast (PC) sequence for blood flow analysis.
      Methods: In a prospective study, 25 patients underwent a CMR examination which included a 3D cine SSFP sequence and a 3D cine PC (also known as 4D flow) sequence acquired during free-breathing and after the administration of a gadolinium-based contrast agent. Both 3D sequences covered the heart and mediastinum, and used retrospective vectorcardiogram gating (20 phases/beat interpolated to 30 phases/beat) and prospective respiratory motion compensation confining data acquisition to end-expiration. Cardiovascular measurements derived from the 3D cine SSFP and PC images were then compared with those from standard 2D imaging.
      Results: All 3D cine SSFP and PC acquisitions were completed successfully. The mean time for the 3D cine sequences including prescription was shorter than that for the corresponding 2D sequences (21 min vs. 36 min, P-value <0.001). Left and right ventricular end-diastolic volumes and stroke volumes by 3D cine SSFP were slightly smaller than those from 2D cine SSFP (all biases ≤5%). The blood flow measurements from the 3D and 2D sequences had close agreement in the ascending aorta (bias -2.6%) but main pulmonary artery flow was lower with the 3D cine sequence (bias -11.2%).
      Conclusion: Compared to the conventional 2D cine approach, a comprehensive 3D cine function and flow examination was faster and yielded slightly lower left and right end-diastolic volumes, stroke volumes, and main pulmonary artery blood flow. This free-breathing 3D cine approach allows flexible post-examination data analysis and has the potential to make examinations more comfortable for patients and easier to perform for the operator.
      (Copyright © 2020 Elsevier Inc. All rights reserved.)
    • Grant Information:
      R01 HL149807 United States HL NHLBI NIH HHS
    • Contributed Indexing:
      Keywords: 3D cine; 4D blood flow; Cardiac MRI; Free-breathing; Ventricular function
    • Accession Number:
      0 (Contrast Media)
    • Publication Date:
      Date Created: 20201009 Date Completed: 20210224 Latest Revision: 20211203
    • Publication Date:
      20221213
    • Accession Number:
      PMC7669675
    • Accession Number:
      10.1016/j.mri.2020.09.026
    • Accession Number:
      33035637