Synchronizing Brain Rhythms to Improve Cognition.

Publisher: Annual Reviews Country of Publication: United States NLM ID: 2985151R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-326X (Electronic) Linking ISSN: 00664219 NLM ISO Abbreviation: Annu Rev Med Subsets: MEDLINE

Publication: Palo Alto Ca : Annual Reviews
Original Publication: Palo Alto, Calif., Annual Reviews, inc.

Brain/*physiopathology ; Circadian Rhythm/*physiology ; Cognition/*physiology ; Cognition Disorders/*therapy ; Transcranial Direct Current Stimulation/*methods; Cognition Disorders/physiopathology ; Humans

Impaired cognition is common in many neuropsychiatric disorders and severely compromises quality of life. Synchronous electrophysiological rhythms represent a core mechanism for sculpting communication dynamics among large-scale brain networks that underpin cognition and its breakdown in neuropsychiatric disorders. Here, we review an emerging neuromodulation technology called transcranial alternating current stimulation that has shown remarkable early results in rapidly improving various domains of human cognition by modulating properties of rhythmic network synchronization. Future noninvasive neuromodulation research holds promise for potentially rescuing network activity patterns and improving cognition, setting groundwork for the development of drug-free, circuit-based therapeutics for people with cognitive brain disorders.

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R01 AG063775 United States AG NIA NIH HHS; R01 MH114877 United States MH NIMH NIH HHS

Keywords: cognition; cognitive deficits; cross-frequency coupling; neuropsychiatric disorders; synchronization; transcranial alternating current stimulation

Date Created: 20201009 Date Completed: 20211029 Latest Revision: 20230404

20240829

PMC10068593

10.1146/annurev-med-060619-022857

33035432