Magnetic Field-Mediated Control of Whole-Cell Biocatalysis.

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  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 101526034 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7185 (Electronic) Linking ISSN: 19487185 NLM ISO Abbreviation: J Phys Chem Lett Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, D.C. : American Chemical Society
    • Subject Terms:
      Biocompatible Materials/*chemistry ; Ethanol/*chemistry ; Glucose/*chemistry ; Magnetic Iron Oxide Nanoparticles/*chemistry ; Saccharomyces cerevisiae/*metabolism; Biocatalysis ; Biosynthetic Pathways ; Cell Membrane Permeability ; Ferrous Compounds/chemistry ; Hydrogen Peroxide/chemistry ; Magnetic Fields ; Models, Chemical ; Oxidation-Reduction ; Surface Properties
    • Abstract:
      For decades, scientists have been looking for a way to control catalytic and biocatalytic processes through external physical stimuli. In this Letter, for the first time, we demonstrate the 150 ± 8% increase of the conversion of glucose to ethanol by Saccharomyces cerevisiae due to the application of a low-frequency magnetic field (100 Hz). This effect was achieved by the specially developed magnetic urchin-like particles, consisting of micrometer-sized core coated nanoneedles with high density, which could provide a biosafe permeabilization of cell membranes in a selected frequency and concentration range. We propose an acceleration mechanism based on magnetic field-induced cell membrane permeabilization. The ability to control cell metabolism without affecting their viability is a promising way for industrial biosynthesis to obtain a beneficial product with genetically engineered cells and subsequent improvement of biotechnological processes.
    • Accession Number:
      0 (Biocompatible Materials)
      0 (Ferrous Compounds)
      3K9958V90M (Ethanol)
      BBX060AN9V (Hydrogen Peroxide)
      IY9XDZ35W2 (Glucose)
    • Publication Date:
      Date Created: 20201009 Date Completed: 20210517 Latest Revision: 20210517
    • Publication Date:
      20221213
    • Accession Number:
      10.1021/acs.jpclett.0c02564
    • Accession Number:
      33035064