Splenic marginal zone lymphoma: a case report and literature review.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101170544 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7819 (Electronic) Linking ISSN: 14777819 NLM ISO Abbreviation: World J Surg Oncol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, 2003-
    • Subject Terms:
      Leukemia, Lymphocytic, Chronic, B-Cell* ; Lymphoma, B-Cell, Marginal Zone*/diagnostic imaging ; Lymphoma, B-Cell, Marginal Zone*/surgery ; Splenic Neoplasms*/surgery; Female ; Humans ; Middle Aged ; Prognosis ; Splenectomy
    • Abstract:
      Background: Splenic marginal zone lymphoma (SMZL) is a rare non-Hodgkin lymphoma, and much little is known about its clinical characteristics and management strategies. Here we present a case of SMZL and review relevant literature to provide a better recognition of this disease entity.
      Case Presentation: A 49-year-old Chinese female was admitted to our hospital with complaints of abdominal distension and acid reflux. Physical examinations and imaging investigations suggested the presence of splenomegaly. Laboratory workups revealed mildly reduced white blood cell count otherwise was not remarkable. The patient underwent splenectomy. Histological examination combined with immunohistochemical analysis of the resected spleen confirmed the diagnosis of SMZL. The patient recovered uneventfully during follow-ups.
      Conclusions: Due to the rarity and unspecific clinical features, SMZL is extremely challenging to be diagnosed preoperatively. Patients with SMZL are generally associated with favorable prognosis. Combining the staging characteristics of non-Hodgkin's lymphoma and splenic primary lymphoma may assist in clinical staging management of SMZL.
    • References:
      AJR Am J Roentgenol. 2009 Mar;192(3):745-53. (PMID: 19234273)
      Cancer. 1984 Oct 15;54(8):1606-19. (PMID: 6548171)
      Ann Oncol. 2014 Jul;25(7):1404-1410. (PMID: 24799461)
      Clin Radiol. 1998 Feb;53(2):137-42. (PMID: 9502091)
      Oncologist. 2013;18(2):190-7. (PMID: 23345547)
      Leuk Lymphoma. 2014 Aug;55(8):1854-60. (PMID: 24206091)
      Leuk Lymphoma. 2012 Mar;53(3):430-4. (PMID: 21848363)
      Mil Med. 2018 Sep 1;183(suppl_2):98-100. (PMID: 30189065)
      Lancet Oncol. 2003 Feb;4(2):95-103. (PMID: 12573351)
      Ecancermedicalscience. 2018 Dec 13;12:887. (PMID: 30792804)
      Leuk Lymphoma. 2014 Jul;55(7):1463-70. (PMID: 24050506)
      Cancer. 1993 Jan 1;71(1):207-15. (PMID: 8416717)
      J Nucl Med. 1992 Jun;33(6):1183-5. (PMID: 1597736)
      Pathol Oncol Res. 2007;13(4):382-4. (PMID: 18158578)
      Leukemia. 2007 Dec;21(12):2547-9. (PMID: 17625607)
      J Hepatol. 2015 Jan;62(1):234-7. (PMID: 25285757)
      Blood. 2002 Sep 1;100(5):1648-54. (PMID: 12176884)
      Haematologica. 1994 May-Jun;79(3):286-93. (PMID: 7926983)
      Eur J Haematol. 2005 Aug;75(2):130-5. (PMID: 16000129)
      J Nucl Med. 2003 Jul;44(7):1072-4. (PMID: 12843223)
      Leukemia. 2008 Mar;22(3):487-95. (PMID: 18094718)
      Tech Innov Patient Support Radiat Oncol. 2017 Sep 06;3-4:23-29. (PMID: 32095563)
      Blood. 2002 Feb 15;99(4):1299-304. (PMID: 11830479)
      Blood. 2006 Jun 15;107(12):4643-9. (PMID: 16493005)
      Br J Haematol. 2015 May;169(4):520-7. (PMID: 25854936)
      Blood. 2016 Apr 28;127(17):2072-81. (PMID: 26989207)
      Best Pract Res Clin Haematol. 2017 Mar - Jun;30(1-2):5-12. (PMID: 28288716)
      Am J Pathol. 1999 May;154(5):1583-9. (PMID: 10329610)
      Ann Hematol. 2014 Mar;93(3):449-58. (PMID: 24057925)
      Clin Lymphoma. 2002 Jun;3(1):41-7. (PMID: 12141954)
      Hematol Oncol. 2003 Dec;21(4):163-8. (PMID: 14735554)
      Toxicol Pathol. 2006;34(5):455-65. (PMID: 17067939)
      Br J Haematol. 2009 Jun;145(6):741-8. (PMID: 19344412)
      J Exp Med. 2012 Aug 27;209(9):1537-51. (PMID: 22891273)
      Nat Rev Immunol. 2005 Aug;5(8):606-16. (PMID: 16056254)
      Oncology (Williston Park). 2012 Feb;26(2):194-202. (PMID: 22489356)
      J Clin Oncol. 2005 Jan 20;23(3):468-73. (PMID: 15659492)
      Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Apr;25(2):600-603. (PMID: 28446319)
    • Contributed Indexing:
      Keywords: Case report; Management; Splenic marginal zone lymphoma; Staging
    • Publication Date:
      Date Created: 20201002 Date Completed: 20210514 Latest Revision: 20210514
    • Publication Date:
      20231215
    • Accession Number:
      PMC7532117
    • Accession Number:
      10.1186/s12957-020-02030-3
    • Accession Number:
      33004051