Is Masked Hypertension an underlying Cause of Unexplained Left Ventricle Hypertrophy?

Publisher: Informa Healthcare Country of Publication: England NLM ID: 9305929 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6006 (Electronic) Linking ISSN: 10641963 NLM ISO Abbreviation: Clin Exp Hypertens Subsets: MEDLINE

Publication: London : Informa Healthcare
Original Publication: New York, N.Y. : Marcel Dekker, Inc., c1993-

Blood Pressure Monitoring, Ambulatory*/methods ; Blood Pressure Monitoring, Ambulatory*/statistics & numerical data ; Heart Ventricles*/diagnostic imaging ; Heart Ventricles*/pathology ; Hypertrophy, Left Ventricular*/diagnosis ; Hypertrophy, Left Ventricular*/etiology ; Hypertrophy, Left Ventricular*/physiopathology ; Masked Hypertension*/complications ; Masked Hypertension*/epidemiology ; Masked Hypertension*/physiopathology; Blood Pressure/physiology ; Echocardiography/methods ; Female ; Humans ; Male ; Middle Aged ; Organ Size ; Prevalence

Objectives: Unexplained left ventricular hypertrophy (ULVH) is defined as increased wall thickness in the absence of conditions that predispose to hypertrophy. The aim of this study was to evaluate the rate of masked hypertension in patient with unexplained left ventricle hypertrophy.
Method: A total of 120 consecutive unexplained left ventricle hypertrophy patients without overt hypertension and diabetes and 121 healthy control subjects were included in the study. After a complete medical history and laboratory examination, patients' height, weight, waist circumference heart rate, and office blood pressure were recorded. All subjects underwent ambulatory blood pressure monitoring, and transthoracic echocardiography.
Results: Mean age were similar between patients with ULVH and controls. There was no significant difference in total cholesterol, HDL, LDL cholesterol and triglyceride levels, left ventricle ejection fraction, between the groups. Prevalence of Masked hypertension was significantly higher in patients with ULVH than controls (28.3% vs 6.6%, p < .001). Left ventricular mass index (141.9 ± 16.8 g/cm ² vs. 67.3 ± 10.3 g/cm ² , p < .001) was significantly higher in masked hypertensive patients with ULVH compared to normotensive ULVH and control subjects.
Conclusion: In this study, we found high prevalence of masked hypertension in ULVH patients. Patients with ULVH should be screened by ABPM to detect possible masked hypertension.

Keywords: Hypertension; ambulatory blood pressure monitoring; hypertrophy; masked hypertension; unexplained left ventricle hypertrophy

Date Created: 20200928 Date Completed: 20210517 Latest Revision: 20210517

20240829

10.1080/10641963.2020.1825729

32985273